美国麻省理工学院Jun R. Huh团队探明了免疫受体的全脑图谱揭示了IL-17E和受体IL-17RB的神经调节作用。这一研究成果发表在2025年4月7日出版的国际学术期刊《细胞》上。
小组绘制了所有主要IL-17R亚基的脑区域特异性表达图谱，发现除了IL-17RA外，IL-17RB而不是IL-17RC通过其在皮质中的表达在社会行为中发挥作用。课题组研究人员进一步发现，在皮质神经元中表达的IL-17E通过作用于表达IL-17RA-和IL-17RB的神经元来增强社会互动。这些发现强调了大脑皮层中调节社会行为的IL-17回路。表征空间受限的细胞因子受体表达可以用来阐明细胞因子如何作为介导神经免疫相互作用的关键信使来塑造动物行为。
据介绍，细胞因子与其受体复合物相互作用，协调各种过程——从免疫反应到行为调节。白细胞介素- 17a （IL-17A）通过结合IL-17受体A （IL-17RA）和IL-17RC亚基介导保护性免疫反应。IL-17A也调节社会互动，但细胞因子受体在这一过程中的作用及其在大脑中的表达仍不清楚。
附：英文原文
Title: Brain-wide mapping of immune receptors uncovers a neuromodulatory role of IL-17E and the receptor IL-17RB
Author: Yunjin Lee, Tomoe Ishikawa, Hyeseung Lee, Byeongjun Lee, Changhyeon Ryu, Irene Davila Mejia, Minjin Kim, Guangqing Lu, Yujin Hong, Mengyang Feng, Hyeyoon Shin, Sylvain Meloche, Richard M. Locksley, Ekaterina Koltsova, Sergei I. Grivennikov, Myriam Heiman, Gloria B. Choi, Jun R. Huh
Issue&Volume: 2025-04-07
Abstract: Cytokines interact with their receptor complexes to orchestrate diverse processes—from immune responses to behavioral modulation. Interleukin-17A (IL-17A) mediates protective immune responses by binding to IL-17 receptor A (IL-17RA) and IL-17RC subunits. IL-17A also modulates social interaction, yet the role of cytokine receptors in this process and their expression in the brain remains poorly characterized. Here, we mapped the brain-region-specific expression of all major IL-17R subunits and found that in addition to IL-17RA, IL-17RB—but not IL-17RC—plays a role in social behaviors through its expression in the cortex. We further showed that IL-17E, expressed in cortical neurons, enhances social interaction by acting on IL-17RA- and IL-17RB-expressing neurons. These findings highlight an IL-17 circuit within the cortex that modulates social behaviors. Thus, characterizing spatially restricted cytokine receptor expression can be leveraged to elucidate how cytokines function as critical messengers mediating neuroimmune interactions to shape animal behaviors.
DOI: 10.1016/j.cell.2025.03.006
Source: https://www.cell.com/cell/abstract/S0092-8674(25)00279-X