RuCo双金属纳米片治疗炎症性肠病的酶模拟活性，这一成果由同济大学施剑林研究小组经过不懈努力而取得。2025年4月2日，国际知名学术期刊《美国化学会杂志》发表了这一成果。

研究团队设计和合成了一种用于治疗IBD的双金属钌钴（RuCo）纳米片。纳米片结构中的Ru-Co原子由于其电负性而表现出显著的电子转移特性。密度泛函理论计算表明，与相应的Ru和Co金属单体相比，RuCo纳米片具有更高的d波段中心，从而提高了催化活性。这种RuCo纳米片具有超氧化物歧化酶和过氧化氢酶样级联酶活性，当暴露于模拟胃液中4小时后，在胃液中表现出良好的稳定性，确保了理想的抗氧化活性保留。细胞和动物研究表明，RuCo纳米片能够有效减少氧化应激，防止肠道部位ROS异常增加引发的炎症反应，并保护细胞免受炎症损伤。本研究提出一种胃酸稳定的抗氧化纳米催化平台，用于有效治疗消化系统的炎症性疾病。

据悉，活性氧（ROS）异常水平的存在是公认的炎症性肠病（IBD）的病理特征。因此，开发具有高抗氧化能力和胃酸耐受性的口服抗氧化剂对治疗IBD具有重要意义。

附：英文原文

Title: Enzyme-Mimic Activities of RuCo Bimetallic Nanosheets for Inflammatory Bowel Disease Treatment

Author: Zhixin Chen, Ya-Xuan Zhu, Yanling You, Min Ge, Yihan Chen, Han Lin, Jianlin Shi

Issue&Volume: April 2, 2025

Abstract: The presence of abnormal levels of reactive oxygen species (ROS) is a recognized pathological feature of inflammatory bowel disease (IBD). Therefore, the development of orally administered antioxidants with high antioxidative capacity and gastric acid tolerance for the treatment of IBD is of great significance. Here, we present the design and synthesis of a bimetallic ruthenium–cobalt (RuCo) nanosheet for the treatment of IBD. The Ru–Co atoms within the nanosheet structure exhibit significant electron transfer properties owing to their electronegativity feature. Density functional theory calculations indicate that the RuCo nanosheets have higher d-band centers than the corresponding Ru and Co metal monoliths, which increases the catalytic activity. Such RuCo nanosheets exhibit superoxide dismutase and catalase-like cascade enzyme activities and show robust stability in gastric fluid over a 4 h period when exposed to simulated gastric fluid, ensuring desirable retention of antioxidative activity. Cellular and animal studies show that RuCo nanosheets are capable of effectively reducing oxidative stress, preventing inflammatory responses triggered by an abnormal increase in ROS at intestinal sites, and thus protecting cells from inflammatory damages. This research presents a gastric-acid-stabilized antioxidative nanocatalytic platform for the efficient treatment of inflammatory diseases of the digestive system.

DOI: 10.1021/jacs.5c00100

Source: https://pubs.acs.org/doi/abs/10.1021/jacs.5c00100