近日，香港中文大学-深圳的唐本忠教授制备了pH响应型AIE光敏剂用于增强抗菌治疗。该项研究成果发表在2025年4月29日出版的《德国应用化学》杂志上。

细菌感染显著改变了局部微环境，细菌代谢产生的酸性副产物导致pH值明显降低。利用这一特性，研究组合成并鉴定了DHTPA，这是一种近红外（NIR）荧光和pH响应聚集诱导发射（AIE）光敏剂，用于增强针对细菌感染的光动力疗法。与中性条件（pH 7.4）相比，DHTPA聚集体在弱酸性条件（pH 5.5）下的ROS产生增加了2.1倍，这归因于其pH依赖性的电子结构调节。 

在近红外光照射下，DHTPA聚集体精确地响应酸性微环境，显著促进ROS的产生，从而有效地根除细菌。体外研究表明，DHTPA对革兰氏阴性菌和革兰氏阳性菌的杀菌效率均超过99.9%。在小鼠感染的伤口模型中，DHTPA治疗可加速伤口愈合2.4倍，显著减少细菌负荷，减轻炎症反应，突出其治疗潜力。通过整合近红外激活、pH响应性和AIE特性，DHTPA提供了一种精确有效的抗菌治疗策略，为细菌感染的临床管理提供了创新的解决方案。

附：英文原文

Title: pH-Responsive AIE Photosensitizers for Enhanced Antibacterial Therapy

Author: Qihang Ding, Lina Ding, Chunbai Xiang, Chunbin Li, Eunji Kim, Changyu Yoon, Haoran Wang, Meijia Gu, Pengfei Zhang, Lin Wang, Ben Zhong Tang, Jong Seung Kim

Issue&Volume: 2025-04-29

Abstract: Bacterial infections significantly alter the local microenvironment, with acidic byproducts from bacterial metabolism leading to a pronounced pH reduction. Leveraging this characteristic, we synthesized and identified DHTPA, a near-infrared (NIR) fluorescent and pH-responsive aggregation-induced emission (AIE) photosensitizer, for enhanced photodynamic therapy against bacterial infections. DHTPA aggregates exhibit a 2.1-fold increase in ROS generation under weakly acidic conditions (pH 5.5) compared to neutral conditions (pH 7.4), attributed to its pH-dependent electronic structure modulation. Upon NIR light irradiation, DHTPA aggregates precisely respond to the acidic microenvironment, significantly boosting ROS production for efficient bacterial eradication. In vitro studies demonstrated that DHTPA achieved over 99.9% bactericidal efficiency against both Gram-negative and Gram-positive bacteria. In a murine infected wound model, DHTPA treatment accelerated wound healing by 2.4 times, markedly reduced bacterial burden, and alleviated inflammatory responses, highlighting its therapeutic potential. By integrating NIR activation, pH responsiveness, and AIE properties, DHTPA presents a precise and efficient antibacterial therapeutic strategy, offering an innovative solution for the clinical management of bacterial infections.

DOI: 10.1002/anie.202506505

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202506505