美国加州大学Cholsoon Jang课题组报道了循环甘油可预测对果糖诱导的肝脂肪变性的恢复能力。该项研究成果发表在2025年4月22日出版的《细胞—代谢》上。

该研究组利用遗传上不同的同源菌株、基于质谱的代谢组学和体内同位素示踪，确定循环甘油作为一种生物标志物，预测两性对果糖诱导的肝脏脂肪变性的恢复能力。研究团队发现，口服果糖后循环甘油的激增反映了小肠强烈的果糖分解代谢。小肠的这种果糖清除与各菌株慢性果糖暴露后肝脏新生脂肪生成和脂肪变性的诱导较弱有关。这些数据表明，口服果糖耐量试验和循环甘油测量在预测个体对果糖引起的脂肪变性肝的易感性和提供个性化饮食建议方面具有潜在的实用性。

据介绍，过量摄入膳食果糖会增加代谢功能障碍相关的脂肪变性肝病（MASLD）、肝硬化和癌症的风险。然而，哪些宿主因素决定疾病易感性尚不完全清楚。

附：英文原文

Title: Circulating glycerate predicts resilience to fructose-induced hepatic steatosis

Author: Cuauhtemoc B. Ramirez, In Sook Ahn, Varvara I. Rubtsova, Ingrid Cely, Johnny Le, Joohwan Kim, Sunhee Jung, Miranda E. Kelly, Yeojin Kim, Hosung Bae, Won-Suk Song, Yasmine H. Alam, Guanglin Zhang, Graciel Diamante, Alina Chao, Lauren Hoffner, Alexis Anica, Izabelle Le, Miranda L. Lopez, Ian J. Tamburini, Elena M. Moyer, Ariel Tsai, Qin Yang, Xing Dai, Daniele Piomelli, Gina Lee, Xia Yang, Cholsoon Jang

Issue&Volume: 2025-04-22

Abstract: Excessive intake of dietary fructose increases the risk of metabolic-dysfunction-associated steatotic liver disease (MASLD), cirrhosis, and cancers. However, what host factors determine disease vulnerability is incompletely understood. Here, we leverage genetically divergent mouse strains, mass spectrometry-based metabolomics, and in vivo isotope tracing, identifying circulating glycerate as a biomarker that predicts resilience to fructose-induced hepatic steatosis in both sexes. We found that the surge of circulating glycerate after an oral fructose provision reflects strong small-intestinal fructose catabolism. Such fructose clearance by the small intestine is linked to a weaker induction of hepatic de novo lipogenesis and steatosis upon chronic fructose exposure across strains. These data indicate the potential utility of an oral fructose tolerance test and circulating glycerate measurements to predict an individual's susceptibility to fructose-elicited steatotic liver and provide personalized dietary recommendations.

DOI: 10.1016/j.cmet.2025.03.017

Source: https://www.cell.com/cell-metabolism/abstract/S1550-4131(25)00209-8