宁波大学王钦文研究小组报道了全身病理变化对阿尔茨海默病的诊断和治疗有哪些启示。这一研究成果发表在2025年4月21日出版的国际学术期刊《神经科学通报》上。

在本文中，该课题组研究人员回顾了AD与其他系统疾病之间的关系。此外，该团队主要从阿尔茨海默病的病理角度，总结了与阿尔茨海默病和其他系统疾病相关的可能机制。针对阿尔茨海默病与全身性病理改变的关系，该研究组旨在为阿尔茨海默病的早期预警信号和治疗提供新的前景，如建立基于更容易获取的外周样本的诊断和筛查系统。

据了解，阿尔茨海默病（Alzheimer ''s disease， AD）被认为是一种神经退行性疾病，有研究认为AD可能是一种全身性疾病。研究报告了非神经系统疾病与阿尔茨海默病之间的联系。阿尔茨海默病病理与全身（非神经系统）病理改变之间的相关性是复杂的，这些相关性及其因果关系的机制尚不清楚。

附：英文原文

Title: What Information do Systemic Pathological Changes Bring to the Diagnosis and Treatment of Alzheimer’s Disease

Author: Zhou, Jinyue, Sun, Xiaoli, Wang, Keren, Shen, Min, Yu, Jingbo, Yao, Qi, Hong, Hang, Tang, Chunlan, Wang, Qinwen

Issue&Volume: 2025-04-21

Abstract: Alzheimer’s disease (AD) is regarded as a neurodegenerative disease, and it has been proposed that AD may be a systemic disease. Studies have reported associations between non-neurological diseases and AD. The correlations between AD pathology and systemic (non-neurological) pathological changes are intricate, and the mechanisms underlying these correlations and their causality are unclear. In this article, we review the association between AD and disorders of other systems. In addition, we summarize the possible mechanisms associated with AD and disorders of other systems, mainly from the perspective of AD pathology. Regarding the relationship between AD and systemic pathological changes, we aim to provide a new outlook on the early warning signs and treatment of AD, such as establishing a diagnostic and screening system based on more accessible peripheral samples.

DOI: 10.1007/s12264-025-01399-z

Source: https://link.springer.com/article/10.1007/s12264-025-01399-z