厦门大学刘刚课题组研制了镧系纳米粒子-聚集诱导发射光敏剂复合系统驱动耦合三重态能量传递用于增强放射光动力治疗。2025年4月1日出版的《美国化学会杂志》发表了这项成果。

切伦科夫光（CL）作为光动力治疗（PDT）的内部激发源，解决了激光穿透的局限性，并具有将临床放射治疗与光疗无缝集成的巨大潜力。然而，CL介导的PDT的有效性明显受到挑战的阻碍，例如CL的低强度和CL供体与光敏剂（ps）之间的能量传递不足。在这项研究中，介绍了一种新的方法来增强放射性核素激活的放射光动力治疗，利用由镧系纳米粒子和聚集诱导发射光敏剂（AIE PS）组成的混合纳米粒子系统，命名为LnNP-TQ NPs。该系统使镧系纳米粒子能够优化放射性核素的衰变能量，通过三重态能量转移（TET）介导的过程有效地敏化AIE PS，效率接近100%。当被临床放射性核素18F激活用于正电子发射断层成像时，LnNP-TQ NPs通过有效的单线态氧（1O2）生成显著抑制肿瘤生长。该策略优化利用放射性核素能量，实现高效的能量转移，为提高肿瘤放疗-光疗疗效提供了一条有希望的途径。

附：英文原文

Title: A Lanthanide Nanoparticle–Aggregation-Induced Emission Photosensitizer Complex System Drives Coupled Triplet Energy Transfer for Enhanced Radio-Photodynamic Therapy

Author: Yibo An, Dazhuang Xu, Pan He, Ziying Wang, Yun Li, Jiang Ming, Renyuan Liu, Jingchao Li, Zhixiang Lu, Gang Liu

Issue&Volume: April 1, 2025

Abstract: Cerenkov light (CL), utilized as an internal excitation source for photodynamic therapy (PDT), addresses the limitations of laser penetration and has substantial potential for seamlessly integrating clinical radiotheranostics with phototheranostics. Nevertheless, the effectiveness of CL-mediated PDT is significantly hindered by challenges, such as the low intensity of CL and inadequate energy transfer between the CL donor and photosensitizers (PSs). In this study, a novel approach is introduced for enhanced radionuclide-activated radio-photodynamic therapy utilizing a hybrid nanoparticle system composed of lanthanide nanoparticles and an aggregation-induced emission photosensitizer (AIE PS), designated LnNP–TQ NPs. This system enables lanthanide nanoparticles to optimize the decay energy of radionuclides, effectively sensitizing the AIE PS through triplet energy transfer (TET)-mediated processes with an efficiency approaching 100%. When activated by the clinical radionuclide 18F for positron emission tomography imaging, the LnNP–TQ NPs substantially inhibited tumor growth via effective singlet oxygen (1O2) generation. This strategy, which optimally harnesses radionuclide energy and achieves efficient energy transfer, offers a promising pathway for enhancing radiotherapy–phototherapy efficacy in tumor treatment.

DOI: 10.1021/jacs.4c18033

Source: https://pubs.acs.org/doi/abs/10.1021/jacs.4c18033