小麦串联激酶激活NLR触发免疫，这一成果由
在本研究中，研究小组发现SR62位点是一个编码Sr62TK和NLR （Sr62NLR）的基因模块，并鉴定了相应的AvrSr62效应子。AvrSr62结合Sr62TK的N端激酶1，触发激酶2的位移，从而激活Sr62NLR。建模和突变分析表明，这是由(i)结合AvrSr62和激酶2的激酶1和（ii）结合激酶1和Sr62NLR的激酶2上的重叠结合位点介导的。了解这种双组分抗性复合体可能有助于设计和育种具有持久抗性的植物。
据悉，核苷酸结合富亮氨酸重复序列（NLR）受体在植物免疫中的作用已经得到了很好的研究，但一类串联激酶（TKs）在小麦和大麦中赋予抗病能力的功能尚不清楚。
附：英文原文
Title: A wheat tandem kinase activates an NLR to trigger immunity
Author: Renjie Chen, Jian Chen, Oliver R. Powell, Megan A. Outram, Taj Arndell, Karthick Gajendiran, Yan L. Wang, Jibril Lubega, Yang Xu, Michael A. Ayliffe, Cheryl Blundell, Melania Figueroa, Jana Sperschneider, Thomas Vanhercke, Kostya Kanyuka, Dingzhong Tang, Guitao Zhong, Catherine Gardener, Guotai Yu, Spyridon Gourdoupis, ukasz Jaremko, Oadi Matny, Brian J. Steffenson, Willem H. P. Boshoff, Wilku B. Meyer, Stefan T. Arold, Peter N. Dodds, Brande B. H. Wulff
Issue&Volume: 2025-03-28
Abstract: The role of nucleotide-binding leucine-rich repeat (NLR) receptors in plant immunity is well studied, but the function of a class of tandem kinases (TKs) that confer disease resistance in wheat and barley remains unclear. In this study, we show that the SR62 locus is a digenic module encoding the Sr62TK TK and an NLR (Sr62NLR), and we identify the corresponding AvrSr62 effector. AvrSr62 binds to the N-terminal kinase 1 of Sr62TK, triggering displacement of kinase 2, which activates Sr62NLR. Modeling and mutation analysis indicated that this is mediated by overlapping binding sites (i) on kinase 1 for binding AvrSr62 and kinase 2 and (ii) on kinase 2 for binding kinase 1 and Sr62NLR. Understanding this two-component resistance complex may help engineering and breeding plants for durable resistance.
DOI: adp5034
Source: https://www.science.org/doi/10.1126/science.adp5034