近日，Nicholas B. Turk-Browne及其课题组揭示了人类婴儿的海马记忆编码。相关论文于2025年3月21日发表于国际顶尖学术期刊《科学》杂志上。

课题组研究人员通过功能性磁共振成像扫描醒着的婴儿在执行后续记忆任务时的大脑，来研究这种婴儿健忘症的机制基础。海马区在观看以前未见过的照片时的更大活动与1岁左右开始的基于记忆的外观行为有关，这表明编码个人记忆的能力在婴儿期就开始了。在人类生命的一段时间里，情景记忆的编码机制的可用性后来从他们的自传体记录中消失，这意味着后编码机制，即婴儿时期的记忆变得无法检索，可能对婴儿健忘症负有更大的责任。

研究人员表示，人类缺乏对生命最初几年特定事件的记忆。

附：英文原文

Title: Hippocampal encoding of memories in human infants

Author: Tristan S. Yates, Jared Fel, Dawoon Choi, Juliana E. Trach, Lillian Behm, Cameron T. Ellis, Nicholas B. Turk-Browne

Issue&Volume: 2025-03-21

Abstract: Humans lack memories for specific events from the first few years of life. We investigated the mechanistic basis of this infantile amnesia by scanning the brains of awake infants with functional magnetic resonance imaging while they performed a subsequent memory task. Greater activity in the hippocampus during the viewing of previously unseen photographs was related to later memory-based looking behavior beginning around 1 year of age, suggesting that the capacity to encode individual memories comes online during infancy. The availability of encoding mechanisms for episodic memory during a period of human life that is later lost from our autobiographical record implies that postencoding mechanisms, whereby memories from infancy become inaccessible for retrieval, may be more responsible for infantile amnesia.

DOI: adt7570

Source: https://www.science.org/doi/10.1126/science.adt7570