华南理工大学化学化工学院伍婉卿小组揭示了可见光诱导异氰酸酯芳基化/烷基化/磷酸化的EDA复合物活化。2025年3月20日出版的《中国化学》发表了这项成果。

本文报道了由芳基硫鎓盐衍生的芳基自由基在异氰化物的芳基化反应中作为偶联伙伴，同时作为醚和二芳基膦氧化物形成烷基和磷基自由基的引发剂。这种级联环化反应产生各种芳基化、烷基化和磷酸化的杂芳烃化合物。值得注意的是，这种转化可以在没有金属或光催化剂的帮助下实现，表现出广泛的衬底适用性和操作简单性。机理研究表明自由基过程和电子供体-受体（EDA）复合物参与了这种转化。

附：英文原文

Title: Visible Light-Induced Arylation/Alkylation/Phosphorylation of Isocyanides via EDA Complex Activation

Author: Shichao Yang, Xiangwen Tan, Dan Liu, Huanfeng Jiang, Wanqing Wu

Issue&Volume: 2025-03-20

Abstract: Herein, it is reported that the aryl radicals derived from aryl thianthrenium salts are used as coupling partner in the arylation reactions of isocyanides, simultaneously as initiators for the formation of alkyl and phosphoryl radicals from ethers and diarylphosphine oxides. This cascade cyclization reaction leads to diverse arylated, alkylated and phosphorylated heteroaromatic compounds. Notably, this transformation can be achieved without the aid of metals or photocatalysts, exhibiting a wide substrate applicability and operational simplicity. Mechanistic studies suggest the involvement of radical processes and electron donor-acceptor (EDA) complexes in this transformation.

DOI: 10.1002/cjoc.70000

Source: https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.70000