杭州师范大学吕亚婷研究团队报道了辅助运动区作为一个灵活的中枢，介导运动序列学习中的行为和神经可塑性变化。相关论文发表在2025年3月13日出版的《神经科学通报》杂志上。

已经尝试通过重复经颅磁刺激来调节运动序列学习（MSL），目标是感觉运动网络中的不同部位。

然而，与MSL相关的神经可塑性调节作用的最佳靶点尚不清楚。因此，本研究旨在比较左初级运动皮层和左辅助运动区（SMAp）在不同复杂程度和双手的MSL调节中的作用，以及相关的神经可塑性，方法是采用间歇性θ波爆发刺激、脑电图和并发经颅磁刺激。他们的数据证明了SMAp刺激在调节神经通讯以支持MSL方面的作用，这是通过促进区域激活和协调分布的大脑区域之间的神经耦合来实现的，特别是在半球间连接中。这些发现可能具有重要的临床意义，特别是对中风后患者等人群的运动康复。

附：英文原文

Title: The Supplementary Motor Area as a Flexible Hub Mediating Behavioral and Neuroplastic Changes in Motor Sequence Learning: A TMS and TMS-EEG Study

Author: Chen, Jing, Fan, Yanzi, Jia, Xize, Fan, Fengmei, Wang, Jinhui, Zou, Qihong, Chen, Bing, Che, Xianwei, Lv, Yating

Issue&Volume: 2025-03-13

Abstract: Attempts have been made to modulate motor sequence learning (MSL) through repetitive transcranial magnetic stimulation, targeting different sites within the sensorimotor network. However, the target with the optimum modulatory effect on neural plasticity associated with MSL remains unclarified. This study was therefore designed to compare the role of the left primary motor cortex and the left supplementary motor area proper (SMAp) in modulating MSL across different complexity levels and for both hands, as well as the associated neuroplasticity by applying intermittent theta burst stimulation together with the electroencephalogram and concurrent transcranial magnetic stimulation. Our data demonstrated the role of SMAp stimulation in modulating neural communication to support MSL, which is achieved by facilitating regional activation and orchestrating neural coupling across distributed brain regions, particularly in interhemispheric connections. These findings may have important clinical implications, particularly for motor rehabilitation in populations such as post-stroke patients.

DOI: 10.1007/s12264-025-01375-7

Source: https://link.springer.com/article/10.1007/s12264-025-01375-7