北京师范大学张鸣沙研究组在研究中取得进展。他们揭示了前额叶和后顶叶皮层在产生多步扫视中的作用。该项研究成果发表在2025年3月11日出版的《神经科学通报》上。

课题组最近提出，MSS是由期望和执行的扫视之间的差异触发的。因此，与跳眼计划和执行有关的大脑区域可能在MSS的产生中起作用。为了验证这一假设，研究人员通过两个实验探索了前额叶（PFC）和后顶叶皮层（PPC）在产生MSS中的作用：当参与者执行间隙扫视任务时，脑电图记录和单脉冲经颅磁刺激人类的PFC或PPC。该研究团队发现PFC和PPC参与了MSS的产生。

研究人员表示，虽然在健康人群中偶尔有多步扫视（MSS）的报道，但在帕金森病（PD）患者中更为明显。因此，MSS已被建议作为PD诊断的生物学标志物。然而，对MSS产生的神经机制的不明确在很大程度上阻碍了它们在临床中的应用。

附：英文原文

Title: The Role of Prefrontal and Posterior Parietal Cortex in Generating Multiple Step Saccades

Author: Ma, Wenbo, Ding, Zhaohuan, Feng, Leixiao, Li, Xiaoli, Zhang, Mingsha

Issue&Volume: 2025-03-11

Abstract: While multiple step saccades (MSS) are occasionally reported in the healthy population, they are more evident in patients with Parkinson’s disease (PD). Therefore, MSS has been suggested as a biological marker for the diagnosis of PD. However, the lack of clarity on the neural mechanism underlying the generation of MSS largely impedes their application in the clinic. We have proposed recently that MSS are triggered by the discrepancy between desired and executed saccades. Accordingly, brain regions involved in saccadic planning and execution might play a role in the generation of MSS. To test this hypothesis, we explored the role of the prefrontal (PFC) and posterior parietal cortex (PPC) in generating MSS by conducting two experiments: electroencephalographic recording and single-pulse transcranial magnetic stimulation in the PFC or PPC of humans while participants were performing a gap saccade task. We found that the PFC and PPC are involved in the generation of MSS.

DOI: 10.1007/s12264-025-01377-5

Source: https://link.springer.com/article/10.1007/s12264-025-01377-5