牛津大学Timothy E. J. Behrens课题组取得一项新突破。他们揭示了通过合成和回放在海马体形成中构建未来行为。该研究于2025年3月10日发表于国际一流学术期刊《自然—神经科学》杂志上。

在这里，研究人员主题模拟和海马记录来调和这些观点。研究人员表明，如果状态空间是由现有的构建块或原语组成的，海马体反应可以被解释为组合记忆，将这些原语结合在一起。至关重要的是，这使代理能够在没有新学习的新环境中表现最佳，直接从组合中推断行为。研究组预测海马体重放在构建和巩固这些组合记忆中的作用。研究组在两个数据集中测试了这些预测，表明来自新发现的地标的重播事件诱导并加强了新的远程射击场。当地标被移动时，重播在与新位置相同的矢量上建立一个新的射击场。总之，这些发现提供了一个关于组合记忆的推理框架，并证明这些记忆是在海马体回放中形成的。

研究人员表示，海马体对记忆、想象力和建设性推理至关重要。最近的模型表明，它的神经元反应可以用状态空间来很好地解释，这种状态空间模拟了经历之间的转换。

附：英文原文

Title: Constructing future behavior in the hippocampal formation through composition and replay

Author: Bakermans, Jacob J. W., Warren, Joseph, Whittington, James C. R., Behrens, Timothy E. J.

Issue&Volume: 2025-03-10

Abstract: The hippocampus is critical for memory, imagination and constructive reasoning. Recent models have suggested that its neuronal responses can be well explained by state spaces that model the transitions between experiences. Here we use simulations and hippocampal recordings to reconcile these views. We show that if state spaces are constructed compositionally from existing building blocks, or primitives, hippocampal responses can be interpreted as compositional memories, binding these primitives together. Critically, this enables agents to behave optimally in new environments with no new learning, inferring behavior directly from the composition. We predict a role for hippocampal replay in building and consolidating these compositional memories. We test these predictions in two datasets by showing that replay events from newly discovered landmarks induce and strengthen new remote firing fields. When the landmark is moved, replay builds a new firing field at the same vector to the new location. Together, these findings provide a framework for reasoning about compositional memories and demonstrate that such memories are formed in hippocampal replay.

DOI: 10.1038/s41593-025-01908-3

Source: https://www.nature.com/articles/s41593-025-01908-3