可进化性的实验进化，这一成果由各国马克斯·普朗克进化生物学研究所
在这项工作中，该团队报告了通过细菌实验群体的局部超突变来增强可进化性的进化。进化的机制类似于在致病菌中观察到的偶然性位点的易突变序列。这一结果的核心是一个谱系水平的选择过程，其中成功取决于在两种表型状态之间进化的能力。随后的进化表明，超可变位点本身也随着环境变化频率的变化而进化。具有局部高变异性的谱系更有可能获得额外的适应性突变，这揭示了一个意想不到的好处。
据悉，可进化性——产生适应性变异的能力——是一种可以通过自然选择进化的特性。然而，突变可能偏向于适应性结果的观点仍然存在争议。
附：英文原文
Title: Experimental evolution of evolvability
Author: Michael Barnett, Lena Meister, Paul B. Rainey
Issue&Volume: 2025-02-21
Abstract: Evolvability—the capacity to generate adaptive variation—is a trait that can itself evolve through natural selection. However, the idea that mutation can become biased toward adaptive outcomes remains controversial. In this work, we report the evolution of enhanced evolvability through localized hypermutation in experimental populations of bacteria. The evolved mechanism is analogous to the mutation-prone sequences of contingency loci observed in pathogenic bacteria. Central to this outcome was a lineage-level selection process, where success depended on the capacity to evolve between two phenotypic states. Subsequent evolution showed that the hypermutable locus is itself evolvable with respect to alterations in the frequency of environmental change. Lineages with localized hypermutability were more likely to acquire additional adaptive mutations, revealing an unanticipated benefit.
DOI: adr2756
Source: https://www.science.org/doi/10.1126/science.adr2756