西北农林大学王存团队在研究中取得进展。他们的最新研究探明了质膜相关钙信号调节拟南芥锌稳态。相关论文发表在2025年2月13日出版的《科学通报》杂志上。

在本研究中，课题组研究人员发现Ca²⁺-CBL1/4/5/8/9-CIPK3/9/23/26-ZIP12信号模块能有效响应拟南芥缺锌，调控Zn稳态。

此外，该团队确定CIPK3/9/23/26与Zn转运体ZIP12相互作用，并主要在Ser185位点磷酸化它。这一磷酸化事件对ZIP12蛋白的稳定性至关重要，表明它调节了ZIP12在锌运输中的功能。总的来说，他们的发现确定了一个质膜相关的钙信号通路，调节拟南芥的锌稳态。这条途径为分子育种方法提供了一个有希望的靶点，旨在培养具有增强锌缺乏耐受性的作物。

据介绍，锌（Zn）是所有生物必需的微量元素，缺乏锌会严重影响作物的产量和品质。然而，对植物锌信号感知和转导的调控机制的了解仍然有限。

附：英文原文

Title: Plasma membrane-associated calcium signaling modulates zinc homeostasis in Arabidopsis

Author: Cun Wang a c

Issue&Volume: 2025/02/13

Abstract: Zinc (Zn) is a crucial micronutrient for all organisms, and its deficiency can significantly hamper crop yield and quality. However, the understanding of the regulatory mechanisms involved in plant Zn signal perception and transduction remains limited. In this study, we discovered that the Ca²⁺-CBL1/4/5/8/9-CIPK3/9/23/26-ZIP12 signaling module effectively responds to Zn deficiency and regulates Zn homeostasis in Arabidopsis thaliana. Furthermore, we determined that CIPK3/9/23/26 interact with the Zn transporter ZIP12 and phosphorylate it primarily at Ser185. This phosphorylation event was crucial for the stability of the ZIP12 protein, suggesting that it regulates the function of ZIP12 in Zn transport. Collectively, our findings identify a plasma membrane-associated calcium signaling pathway that regulates Zn homeostasis in Arabidopsis thaliana. This pathway represents a promising target for molecular breeding approaches aimed at developing crops with enhanced tolerance to Zn deficiency.

DOI: 10.1016/j.scib.2025.02.010

Source: https://www.sciencedirect.com/science/article/abs/pii/S2095927325001690