哈尔滨医科大学冷晓萍研究团队的最新研究探明了利用可重构涡状纳米机器人群突破溶栓治疗中层流的限制。2025年2月12日，国际知名学术期刊《德国应用化学》发表了这一成果。

该研究团队报告了一种受生物启发的策略，在这种策略中，可重构涡旋状的磁性游泳纳米机器人群主动破坏层流，以类似于细菌寻找食物的方式传递药物。药物从可生物降解的亚微米五聚糖烧瓶状纳米机器人的腔体中释放出来，在旋转磁场下聚集成动态旋转的药液。在大鼠下腔静脉狭窄血栓形成模型中，旋涡状纳米机器人群成功地克服了血栓附近的层流屏障。

此外，在大鼠深静脉血栓形成模型中进一步证实了纳米机器人群在打破层流后通过药物聚集增强溶栓效果的临床可行性。这种仿生主动靶向方法克服层流屏障，限制了群体诱导的涡流流体对药物的释放，有利于靶向给药，有望成为一种提高给药效率的创新方法。

研究人员表示，层流是血液循环的正常生理状态，同时也是药物向病变部位有效扩散的天然生理屏障。

附：英文原文

Title: Breaking the Limitation of Laminar Flow in Thrombolytic Therapy with Reconfigurable Vortexlike Nanobot Swarms

Author: Qiang He, Tingxin Yang, Tieyan Si, Yingjie Wu, Jinhong Liu, Luru Dai, Xiankun Lin, Mingjun Xuan, Xiaoping Leng

Issue&Volume: 2025-02-12

Abstract: Laminar blood flow represents the normal physiological state of blood circulation, but it also acts as a natural physiological barrier for the effective diffusion of drugs to the lesion site. Here, we report a bioinspired strategy in which reconfigurable vortexlike swarms of magnetic swimming nanobots actively disrupt the laminar flow to deliver drugs in a manner similar to how bacteria seek food. The drug was released from the cavity of biodegradable, submicron pentosan flask-like nanobots, aggregates as the dynamic rotating drug fluid under a rotating magnetic field. The vortexlike nanobot swarm successfully overcame the laminar barrier near the thrombus in a rat inferior vena cava stenosis thrombosis model, which was observed by ultrasound blood flow imaging. Furthermore, the clinical feasibility of nanobots swarm for enhancing thrombolytic efficacy through drug aggregation after breaking the laminar flow was further confirmed in a rat deep vein thrombosis model. This bionic active targeting approach overcomes the laminar flow barrier and restricts the release of drugs by the swarm-induced vortex fluid to facilitate targeted drug delivery, which is expected to be an innovative method to enhance drug delivery efficiency.

DOI: 10.1002/anie.202425189

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202425189