近日，以色列内盖夫本古里安大学Ilan Dinstein小组的最新研究提出了一个开放的科学资源，用于加速自闭症和其他神经发育疾病的可扩展数字健康研究。2025年12月30日，国际知名学术期刊《自然—神经科学》发表了这一成果。

在这里，研究小组提出了可用的协调数据的广度，并表明，与家长报告相比，数字设备具有更高的准确性和可靠性。数据显示，自闭症儿童比他们的兄弟姐妹有更长的睡眠潜伏期，而更长的潜伏期与所有参与者的行为困难有关，与诊断无关。结果突出了主题化数字设备的优势，并展示了SSP为研究自闭症和开发广泛的数字表型技术提供的机会。

据了解，西蒙斯睡眠项目（SSP）是一项开放科学研究，旨在加速自闭症儿童睡眠和日常行为的数字健康研究。SSP包含来自Dreem3脑电图头带、多传感器智能手表和Withings睡眠垫的数据，以及家长问卷和每日睡眠日记。它包含来自102名特发性自闭症儿童（年龄10-17岁）及其98名非自闭症兄弟姐妹超过3600个昼夜的采集数据，并使所有参与者能够获得全外显子组测序数据访问权限。

附：英文原文

Title: An open science resource for accelerating scalable digital health research in autism and other neurodevelopmental conditions

Author: Hacohen, Micha, Levy, Adam, Kaiser, Hadas, Green Snyder, LeeAnne, Amatya, Alpha, Gundersen, Brigitta B., Spiro, John E., Dinstein, Ilan

Issue&Volume: 2025-12-30

Abstract: The Simons Sleep Project (SSP) is an open-science resource designed to accelerate digital health research into sleep and daily behaviors of autistic children. The SSP contains data from Dreem3 EEG headbands, multi-sensor EmbracePlus smartwatches and Withings’ sleep mats, as well as parent questionnaires and daily sleep diaries. It contains data from >3,600days and nights collected from 102 children (aged 10–17years) with idiopathic autism and 98 of their nonautistic siblings, and enables access to whole-exome sequencing for all participants. Here we present the breadth of available harmonized data and show that digital devices have higher accuracy and reliability compared to parent reports. The data show that autistic children have longer sleep-onset latencies than their siblings and longer latencies are associated with behavioral difficulties in all participants, regardless of diagnosis. The results highlight the advantages of using digital devices and demonstrate the opportunities afforded by the SSP to study autism and develop broad digital phenotyping techniques.

DOI: 10.1038/s41593-025-02146-3

Source: https://www.nature.com/articles/s41593-025-02146-3