DynamicAtlas：果蝇发育的形态动力学图谱，这一成果由加州大学Sebastian J. Streichan小组经过不懈努力而取得。相关论文发表在2025年12月24日出版的《自然—方法学》杂志上。

在这里，该研究组展示了DynamicAtlas：一个来自500个黑腹果蝇胚胎（野生型和18个突变型）的动态和静态数据集的“形态动态图谱”，与一个共同的形态时间轴对齐。令人惊讶的是，野生型表面组织流动的特征揭示了不同的“形态动力学模块”——在这段时间内，整体运动模式是静止的——与关键的发育阶段相对应。突变体分析显示，固定的血流模式依赖于沿背腹轴破坏空间对称性的基因。温度扰动表明形态动力学模块的变化响应于累积的组织变形，而不是经过的时间。将他们的方法扩展到胚胎果蝇中肠，该课题组研究人员在动态三维表面的协变测量中发现模块。DynamicAtlas为研究生命系统的形状形成提供了一个高分辨率的框架。

据悉，生物体的形状是通过基因表达和力学的相互作用而形成的。虽然静态样本的地图集表征细胞命运和基因调控，但了解动态形状变化需要实时成像。

附：英文原文

Title: DynamicAtlas: a morphodynamic atlas for Drosophila development

Author: Lefebvre, Matthew F., Jain-Sharma, Vishank, Claussen, Nikolas, Mitchell, Noah P., Raich, Marion K., Gustafson, Hannah J., Streichan, Friederike E., Bausch, Andreas R., Streichan, Sebastian J.

Issue&Volume: 2025-12-24

Abstract: Living organisms develop their shape through the interplay of gene expression and mechanics. While atlases of static samples characterize cell fates and gene regulation, understanding dynamic shape changes requires live imaging. Here we present DynamicAtlas: a ‘morphodynamic atlas’ of live and static datasets from 500 Drosophila melanogaster embryos (wild type and 18 mutants), aligned to a common morphological timeline. Surprisingly, characterizing wild-type surface tissue flows reveals distinct ‘morphodynamic modules’—time periods in which the global pattern of motion is stationary—corresponding to key developmental stages. Mutant analysis shows stationary flow patterns depend on genes that break spatial symmetry along the dorsal–ventral axis. Temperature perturbations indicate that morphodynamic modules change in response to accumulated tissue deformation, rather than elapsed time. Extending our approach to the embryonic Drosophila midgut, we find modules in covariant measures of the dynamic three-dimensional surface. DynamicAtlas provides a high-resolution framework for studying shape formation across living systems.

DOI: 10.1038/s41592-025-02897-8

Source: https://www.nature.com/articles/s41592-025-02897-8