植物病害控制的细菌营养策略，这一成果由吉林农业大学
研究团队发现AvrBs2是一种由甘油磷酸二酯酶衍生的合成酶，它能催化尿苷5' -二磷酸-α-d-半乳糖生成糖磷酸二酯，即双-(1,6)-环二聚体α-d-半乳糖-磷酸，即黄原糖。黄原糖在宿主细胞中由AvrBs2合成并释放到胞外空间。黄单胞菌通过XanT转运体摄取黄原糖，并通过XanP磷酸二酯酶将其水解以获取营养。AvrBs2、XanT和XanP形成一个黄原糖“生成-吸收-利用”系统，为黄原糖提供专门的营养策略。
此外，AvrBs2-XanT-XanP毒力机制的阐明激发了他们开发一种“抗营养”策略，该策略应适用于控制各种黄单胞菌疾病。
据了解，黄单胞菌属在400多种植物中引起严重的真菌病害。保守的AvrBs2家族效应子是黄单胞菌中最重要的毒力因子之一，但AvrBs2如何促进感染仍不清楚。
附：英文原文
Title: A bacterial nutrition strategy for plant disease control
Author: Shanzhi Wang, Lisong Zhu, Meng Tian, Wenyi Wu, Xu Hu, Xuan Li, Jiyang Wang, Ying Zhu, Jiaqing Xu, Baohui Mou, Jiyun Yang, Fuhao Cui, Dayong Li, Jie Cheng, Zhilong Liu, Ming-An Wang, Linlu Qi, Weiwei Jin, Zhao-Qing Luo, Pei Zhou, Yong-Hwan Lee, Brian Staskawicz, Sheng Yang He, Wenxian Sun
Issue&Volume: 2025-12-18
Abstract: Xanthomonas spp. cause serious diseases in more than 400 plant species. The conserved AvrBs2 family effectors are among the most important virulence factors in xanthomonads, but how AvrBs2 promotes infection remains elusive. We found that AvrBs2 is a glycerophosphodiesterase-derived synthetase that catalyzes uridine 5′-diphosphate-α-d-galactose into a sugar phosphodiester, bis-(1,6)-cyclic dimeric α-d-galactose-phosphate, which is referred to as xanthosan. Xanthosan is synthesized by AvrBs2 in host cells and released into apoplastic spaces. Xanthomonas bacteria uptake xanthosan through the XanT transporter and hydrolyze it through the XanP phosphodiesterase for nutrition. AvrBs2, XanT, and XanP form a xanthosan “generation-uptake-utilization” system to provide a dedicated nutritional strategy to feed xanthomonads. Furthermore, elucidation of the AvrBs2-XanT-XanP virulence mechanism inspired us to develop an “anti-nutrition” strategy that should be applicable to control a wide variety of Xanthomonas diseases.
DOI: ady8325
Source: https://www.science.org/doi/10.1126/science.ady8325