哥德堡大学Nicholas J. Ashton课题组近日取得一项新成果。经过不懈努力，他们的最新研究提出了阿尔茨海默病病理特征在社区人群中的患病率。这一研究成果于2025年12月17日发表在国际顶尖学术期刊《自然》上。

在这里，课题组测量了来自挪威人群的57岁以上个体的11486份血浆样本中苏氨酸217的磷酸化tau作为ADNCs的替代标记物。ADNCs的估计患病率随着年龄的增长而增加，从58-69.9岁人群的不到8%增加到90岁以上人群的65.2%。在70岁及以上的参与者中，10%患有临床前阿尔茨海默病，10.4%患有前驱阿尔茨海默病，9.8%患有阿尔茨海默病痴呆。

此外，在70岁或以上的人群中，60%的痴呆患者、32.6%的轻度认知障碍患者和23.5%的认知障碍患者存在ADNCs。他们的研究结果表明，老年人群中阿尔茨海默病的患病率较高，而年轻人群中临床前阿尔茨海默病的患病率低于此前的估计。

研究人员表示，阿尔茨海默病神经病理改变（ADNCs）是认知障碍的主要症状，其患病率仍不确定。最近基于血液的生物标志物使ADNCs1的可扩展评估成为可能。

附：英文原文

Title: Prevalence of Alzheimer’s disease pathology in the community

Author: Aarsland, Dag, Sunde, Anita Lenora, Tovar-Rios, Diego A., Leuzy, Antoine, Fladby, Tormod, Zetterberg, Henrik, Blennow, Kaj, Tan, Kbra, De Santis, Giovanni, Yakoub, Yara, Arslan, Burak, Huber, Hanna, Pola, Ilaria, Grtschel, Lana, Di Molfetta, Guglielmo, Skjellegrind, Hvard K., Selbaek, Geir, Ashton, Nicholas J.

Issue&Volume: 2025-12-17

Abstract: The prevalence of Alzheimer’s disease neuropathological changes (ADNCs), the leading cause of cognitive impairment, remains uncertain. Recent blood-based biomarkers enable scalable assessment of ADNCs1. Here we measured phosphorylated tau at threonine 217 in 11,486 plasma samples from a Norwegian population-based cohort of individuals over 57 years of age as a surrogate marker for ADNCs. The estimated prevalence of ADNCs increased with age, from less than 8% in people 58–69.9 years of age to 65.2% in those over 90 years of age. Among participants aged 70 years or older, 10% had preclinical Alzheimer’s disease, 10.4% had prodromal Alzheimer’s disease and 9.8% had Alzheimer’s disease dementia. Furthermore, among those 70 years of age or older, ADNCs were present in 60% of people with dementia, in 32.6% of those with mild cognitive impairment and in 23.5% of the cognitively unimpaired group. Our findings suggest a higher prevalence of Alzheimer’s disease dementia in older individuals and a lower prevalence of preclinical Alzheimer’s disease in younger groups than previously estimated2.

DOI: 10.1038/s41586-025-09841-y

Source: https://www.nature.com/articles/s41586-025-09841-y