中国医学科学院生物医学工程研究所殷涛团队的最新研究提出了非周期性脑活动调节皮质脊髓兴奋性。这一研究成果于2025年12月12日发表在国际顶尖学术期刊《神经科学通报》上。

该课题组研究人员进行了五部分分析，包括总功率、周期功率、非周期功率、非周期指数和偏移，以评估皮质脊髓兴奋性的功率依赖性。该研究团队发现α和β功率越高，MEP振幅越大。非周期分量比周期分量起着更重要的作用。

此外，与110% RMT相比，120% RMT功率对皮质脊髓输出的影响更小。他们的研究结果强调，非周期成分与皮层兴奋性有关，可能是优化大脑状态依赖的经颅磁刺激方法的一个有价值的参数。

研究人员表示，脑状态依赖性经颅磁刺激（TMS）是一种具有瞬时能量同步的新型时间精确神经调节方法。这种方法的关键是利用瞬时能量来可靠地估计特定的皮层兴奋性。然而，瞬时能量，特别是非周期性脑活动，对皮质脊髓兴奋性的具体影响尚不完全清楚。在他们的研究中，单脉冲TMS在110%的静息运动阈值（RMT）和120%的RMT下刺激初级运动皮层，同时记录脑电图和运动诱发电位（MEP）。

附：英文原文

Title: Aperiodic Brain Activity Modulates Corticospinal Excitability

Author: Jin, Jingna, Wang, Xin, Zhao, Xinyu, Wang, He, Li, Ying, Liu, Zhipeng, Yin, Tao

Issue&Volume: 2025-12-12

Abstract: Brain state-dependent transcranial magnetic stimulation (TMS) synchronizes with instantaneous power and is a novel time-precise neuroregulation approach. The key to this approach is using instantaneous power to reliably estimate specific cortical excitability. However, the specific influence of instantaneous power, particularly aperiodic brain activity, on corticospinal excitability is not fully understood. In our study, single-pulse TMS stimulated the primary motor cortex at 110% resting motor threshold (RMT) and 120% RMT, and the electroencephalography and motor-evoked potentials (MEP) were recorded simultaneously. We conducted a five-part analysis, including total power, periodic power, aperiodic power, the aperiodic exponent, and offset, to evaluate the power dependence of corticospinal excitability. We found that the higher the alpha and beta power were, the greater the MEP amplitudes were. The aperiodic component plays a more critical role than the periodic component. Furthermore, corticospinal output was less affected by power at 120% RMT than at 110% RMT. Our findings highlight that the aperiodic component is associated with cortical excitability and may be a valuable parameter for optimizing brain-state-dependent TMS approaches.

DOI: 10.1007/s12264-025-01559-1

Source: https://link.springer.com/article/10.1007/s12264-025-01559-1