麻省理工学院Laura D. Lewis团队近日取得一项新成果。经过不懈努力，他们研究出睡眠剥夺后的注意力失败与关节神经血管、瞳孔和脑脊液流动动力学有关。2025年10月29日出版的《自然—神经科学》杂志发表了这项成果。

在这里，该研究团队同时对他们进行快速fMRI-EEG测试，以测试睡眠剥夺如何调节人脑的认知、神经和流体动力学。该研究团队证明，在睡眠剥夺后清醒时的注意力失败与一系列脑-体变化紧密协调，包括神经元移位、瞳孔收缩和脑脊液（CSF）流量脉动，指向流体动力学和神经调节状态的耦合系统。在清醒状态下，脑脊液的流动和血流动力学与注意功能相关，在注意损伤后脑脊液会出现脉动。这些动态的时间与神经调节状态调节的血管机制是一致的。睡眠剥夺的注意力成本可能反映了中枢神经调节系统对休息时间的不可抑制的需求，中枢神经调节系统调节神经元和体液生理。

据了解，睡眠不足会迅速破坏认知功能，长期来看会导致神经系统疾病。为什么睡眠剥夺会对认知产生如此深远的影响，目前还没有得到很好的理解。

附：英文原文

Title: Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics

Author: Yang, Zinong, Williams, Stephanie D., Beldzik, Ewa, Anakwe, Stephanie, Schimmelpfennig, Emilia, Lewis, Laura D.

Issue&Volume: 2025-10-29

Abstract: Sleep deprivation rapidly disrupts cognitive function and in the long term contributes to neurological disease. Why sleep deprivation has such profound effects on cognition is not well understood. Here we use simultaneous fast fMRI–EEG to test how sleep deprivation modulates cognitive, neural and fluid dynamics in the human brain. We demonstrate that attentional failures during wakefulness after sleep deprivation are tightly orchestrated in a series of brain–body changes, including neuronal shifts, pupil constriction and cerebrospinal fluid (CSF) flow pulsations, pointing to a coupled system of fluid dynamics and neuromodulatory state. CSF flow and hemodynamics are coupled to attentional function within the awake state, with CSF pulsations following attentional impairment. The timing of these dynamics is consistent with a vascular mechanism regulated by neuromodulatory state. The attentional costs of sleep deprivation may thus reflect an irrepressible need for rest periods driven by a central neuromodulatory system that regulates both neuronal and fluid physiology.

DOI: 10.1038/s41593-025-02098-8

Source: https://www.nature.com/articles/s41593-025-02098-8