近日，华南理工大学郎超团队研究了基于N-杂环碳金属配合物的超高效上行阴离子转运体。相关论文于2025年10月23日发表在《德国应用化学》杂志上。

对生命系统的功能至关重要的是，自然界中的跨膜离子运输激发了合成模拟，促进了治疗、分离、传感和生物电子学的发展。

研究组报道了简单N-杂环碳（NHC）有机金属化合物介导的高效和选择性阴离子运输。以钌（Ru）作为中心金属和离子结合位点，研究组系统地研究了7类有机钌支架，发现NHC基Ru配合物具有非常高的活性和选择性。将研究扩展到更多的金属，Pd， Ag和Cu的NHC配合物也表现出了显著的传输效率，iPrPh-NHC有机铜化合物的EC₅₀低至3.6 pM，超过了最活跃的离子转运体之一，灵菌红素。

值得注意的是，基于NHC的有机金属转运体利用不同的配体结合和膜扩散动力学来产生跨膜电位，并驱动上行离子转运，类似于质子泵和ATP酶。该研究为进一步开发高效、选择性可调、功能独特的有机金属离子转运体奠定了基础。

附：英文原文

Title: Uphill Anion Transporters with Ultrahigh Efficiency Based on N-Heterocyclic Carbene Metal Complexes

Author: Yangyang Lin, Qin Fu, Zhuorui Kang, Yuting Zhu, Haoxuan Yuan, Changxing Ji, Boyu Zhang, Xian Kong, Peng Shi, Chao Lang

Issue&Volume: 2025-10-23

Abstract: Essential to the function of living systems, transmembrane ion transport in nature has inspired synthetic mimics that advance therapeutics, separations, sensing, and bioelectronics. Here, we report highly efficient and selective anion transport mediated by simple N-heterocyclic carbene (NHC) organometallic compounds. Using ruthenium (Ru) as the central metal and ion binding site, we systematically investigated seven classes of organoruthenium scaffolds and found that NHC-based Ru complexes demonstrated exceptionally high activity and selectivity. Extending the study to more metals, NHC complexes of Pd, Ag, and Cu also exhibited remarkable transport efficiency, with the iPrPh-NHC organocopper compound achieving an EC50 as low as 3.6 pM, surpassing one of the most active ion transporters, prodigiosin. Notably, NHC-based organometallic transporters leverage distinct kinetics of ligand binding and membrane diffusion to generate transmembrane potentials, and drive uphill ion transport reminiscent of proton pumps and ATPases. This work provides foundations for further development of organometallic ion transporters with high efficiency, tunable selectivity, and unique functions.

DOI: 10.1002/anie.202518136

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202518136