近日，华中师范大学陈加荣团队报道了可见光驱动1,3-共轭二烯与1,3-二羰基的1,4-氢烷基化反应。相关论文于2025年10月22日发表在《中国化学》杂志上。

研究组公开了一种具有完美原子经济性的共轭二烯的温和、高效的可见光驱动的1,4-氢烷基化。该方案的关键步骤包括从现成的1,3-二羰基催化生成C自由基，然后是自由基1,4加成形成苄基自由基。该方法具有基片适用范围广、操作简单、效率高等特点。这种方法也拓宽了1,3-二羰基化合物的合成用途，促进了药物样分子的后期修饰和进一步的合成转化。初步的机制研究支持该机制。

附：英文原文

Title: Visible-Light-Driven 1,4-Hydroalkylation of 1,3-Conjugated Dienes with 1,3-Dicarbonyls †

Author: Min Gu, Yu-jie Cao, Quan-Qing Zhao, Jia-Rong Chen

Issue&Volume: 2025-10-22

Abstract: A mild and efficient visible-light-driven 1,4-hydroalkylation of conjugated dienes with perfect atom economy, is disclosed. Key steps of this protocol involve catalytic generation of C-radicals from readily available 1,3-dicarbonyls, followed by a radical 1,4-addition to form the benzyl radicals. This method features broad substrate scope, operational simplicity and high efficiency. This approach also broadens the synthetic utility of 1,3-dicarbonyl compounds, facilitating late-stage modifications of drug-like molecules and further synthetic transformations. Preliminary mechanistic studies support the proposed mechanism.

DOI: 10.1002/cjoc.70285

Source: https://onlinelibrary.wiley.com/doi/10.1002/cjoc.70285