美国东北大学Marta Bianciardi研究团队近日取得一项新成果。经过不懈努力，他们报道了使用7特斯拉功能磁共振成像对人类异静内感受系统的皮质和皮质下映射。2025年10月23日，国际知名学术期刊《自然—神经科学》发表了这一成果。

在这里，研究小组复制并扩展了一个大规模系统，该系统支持人脑中的异稳态和内感受，主题是超高精度7特斯拉功能磁共振成像（n=90)，提高亚属和前属前扣带地形和扩大脑干核测绘的精度。他们的功能连接分析为非人类动物通道追踪研究中记录的96%以上的解剖连接提供了确凿的证据。该系统还包括整个系统中密集的内在连接区域，其中一些区域先前被确定为跨越大脑的神经通信骨干的一部分。这些结果强化了全脑系统支持人体内部环境建模和调节的现有证据。

据了解，大脑不断地预测身体的能量需求，并在需求出现之前做好满足的准备——这一过程被称为适应平衡。为了支持适应，大脑不断模拟身体的感觉状态，这一过程被称为内感受。

附：英文原文

Title: Cortical and subcortical mapping of the human allostatic–interoceptive system using 7 Tesla fMRI

Author: Zhang, Jiahe, Chen, Danlei, Deming, Philip, Srirangarajan, Tara, Theriault, Jordan E., Kragel, Philip A., Hartley, Ludger, Lee, Kent M., McVeigh, Kieran, Wager, Tor D., Wald, Lawrence L., Satpute, Ajay B., Quigley, Karen S., Whitfield-Gabrieli, Susan, Barrett, Lisa Feldman, Bianciardi, Marta

Issue&Volume: 2025-10-23

Abstract: The brain continuously anticipates the body’s energetic needs and prepares to meet them before they arise—a process called allostasis. To support allostasis, the brain continually models the body’s sensory state, a process known as interoception. Here we replicate and extend a large-scale system that supports allostasis and interoception in the human brain using ultrahigh precision 7 Tesla functional magnetic resonance imaging (n=90), improving precision in subgenual and pregenual anterior cingulate topography and expanding brainstem nuclei mapping. Our functional connectivity analyses provide corroborating evidence for more than 96% of the anatomical connections documented in nonhuman animal tract-tracing studies. This system also includes regions of dense intrinsic connectivity throughout the system, some of which were identified previously as part of the backbone of neural communication across the brain. These results reinforce the existing evidence for a whole-brain system that supports the modeling and regulation of the body’s internal milieu.

DOI: 10.1038/s41593-025-02087-x

Source: https://www.nature.com/articles/s41593-025-02087-x