中国科学院动物研究所刘光慧团队的最新研究揭示了维生素C对灵长类动物的卵巢具有衰老保护作用。2025年10月14日出版的《细胞—干细胞》发表了这项成果。

利用单细胞转录组时钟，小组发现维生素C可以使卵母细胞的生物年龄降低1.35岁，体细胞的生物年龄降低5.66岁。这种作用部分是由NRF2通路介导的，它可以缓解卵巢细胞的衰老和炎症。他们的发现强调了维生素C在对抗灵长类动物卵巢衰老中的作用，并为开发对抗人类卵巢衰老的干预措施提供了见解。

据了解，卵巢老化在女性生殖健康中起着关键作用，对治疗策略和生活质量产生影响。然而，单一药物制剂减缓灵长类动物卵巢衰老的潜力仍未得到充分开发。他们在猴子身上进行的3.3年研究表明，口服维生素C对卵巢衰老有保护作用。维生素C可以减少关键的衰老生物标志物，包括氧化应激和卵泡消耗。

附：英文原文

Title: Vitamin C conveys geroprotection on primate ovaries

Author: Ying Jing, Huifen Lu, Jingyi Li, Zan He, Liyun Zhao, Chen Zhang, Ziqi Huang, Lixiao Liu, Shuhui Sun, Shuai Ma, Concepcion Rodriguez Esteban, Xiaobing Fu, Guoguang Zhao, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, Si Wang, Guang-Hui Liu

Issue&Volume: 2025-10-14

Abstract: Ovarian aging plays a pivotal role in female reproductive health, with implications for treatment strategies and quality of life. However, the potential of a single pharmaceutical agent to mitigate primate ovarian aging remains largely unexplored. Our 3.3-year study in monkeys demonstrates that oral vitamin C has geroprotective effects against ovarian aging. Vitamin C diminishes key aging biomarkers, including oxidative stress and follicular depletion. Using a single-cell transcriptomic clock, we show that vitamin C can reduce the biological age of oocytes by 1.35 years and somatic cells by 5.66 years. This effect is partly mediated by the NRF2 pathway, which alleviates ovarian cell senescence and inflammation. Our findings highlight the role of vitamin C in combating primate ovarian aging and provide insights for developing interventions against human ovarian aging.

DOI: 10.1016/j.stem.2025.09.008

Source: https://www.cell.com/cell-stem-cell/abstract/S1934-5909(25)00339-X