上海师范大学魏鑫小组揭示水稻抽穗期定量性状基因的遗传互作网络。相关论文于2025年1月6日在线发表于国际学术期刊《遗传学报》。

研究人员使用18K水稻品系鉴定了影响水稻抽穗期的定量性状基因（QTG），及其表观遗传相互作用。研究人员鉴定了264对相互作用的QTL，并构建了这些QTL的综合遗传网络。平均而言，QTL对之间的表观遗传效应估计约为已识别QTL加性效应的12.5%。

值得注意的是，不同抽穗期基因的多个等位基因之间的表观遗传效应存在差异。此外，57对相互作用的QTG，在对12种其他农艺性状的表观遗传效应中也具有显著性。这些已识别的QTL遗传互作，通过近等基因系、酵母双杂交和裂解荧光素酶互补实验进一步验证。

总体而言，该研究提供了一个水稻抽穗期基因的遗传网络，该网络在调控水稻抽穗期及影响多个相关农艺性状中，发挥着至关重要的作用。这个网络为理解水稻定量性状的遗传机制，以及推动分子育种工作提供了基础。

据悉，与水稻抽穗期相关的若干QTG已被鉴定，这一性状是作物生长发育和产量的关键因素，同时这些基因之间存在复杂的相互作用。然而，至今尚未建立这些QTG的综合遗传互作网络。

附：英文原文

Title: Genetic interaction network of quantitative trait genes for heading date in rice

Author: Xin Wei a

Issue&Volume: 2025/01/06

Abstract: Several quantitative trait genes (QTGs) related to rice heading date, a key factor for crop development and yield, have been identified, along with complex interactions among genes. However, a comprehensive genetic interaction network for these QTGs has not yet been established. In this study, we use 18K-rice lines to identify QTGs and their epistatic interactions affecting rice heading date. We identify 264 pairs of interacting QTL and construct a comprehensive genetic network of these QTL. On average, the epistatic effects of QTL pairs are estimated to be approximately 12.5% of additive effects of identified QTL. Importantly, epistasis vary among different alleles of several heading date genes. Additionally, 57 pairs of interacting QTGs are also significant in their epistatic effects on 12 other agronomic traits. The identified QTL genetic interactions are further validated using near-isogenic lines, yeast two-hybrid, and split-luciferase complementation assays. Overall, this study provides a genetic network of rice heading date genes, which plays a crucial role in regulating rice heading date and influencing multiple related agronomic traits. This network serves as a foundation for understanding the genetic mechanisms of rice quantitative traits and for advancing molecular breeding efforts.

DOI: 10.1016/j.jgg.2024.12.019

Source: https://www.sciencedirect.com/science/article/abs/pii/S1673852725000013