美国丹娜-法伯癌症研究所Mohammad Rashidian团队近期取得重要工作进展，他们研究开发了CD45-PET，这是一种稳定的无创炎症成像工具。相关研究成果2025年1月22日在线发表于《自然》杂志上。

据介绍，炎症成像在推动多种疾病的诊断、治疗和预后评估方面具有巨大潜力。目前，缺乏一种能够特异性且灵敏地检测炎症的正电子发射断层扫描（PET）探针是一项关键挑战。

为了填补这一空白，研究人员推出了CD45-PET成像技术。在多个临床前模型中，该技术能够以极高的灵敏度和清晰度检测炎症。在炎症性肺病和肠道疾病模型中，CD45-PET信号的强度与疾病的严重程度呈现出显著的相关性，其表现优于应用最广泛的炎症成像手段（¹⁸F-氟代脱氧葡萄糖PET）。通过纵向的CD45-PET成像，研究人员还能够精准监测组织特异性炎症特征的动态变化。

最后，研究人员开发了一种可用于临床转化的人类CD45-PET探针，该探针在人源化小鼠模型中能够有效检测人类免疫细胞。CD45-PET成像具有显著的临床应用前景，它能够通过对个体患者的炎症特征进行精准的全身评估，为炎症性疾病的诊断和治疗决策提供有力的工具。

附：英文原文

Title: CD45-PET is a robust, non-invasive tool for imaging inflammation

Author: Salehi Farid, Ali, Rowley, Jennifer E., Allen, Harris H., Kruger, Isabella G., Tavakolpour, Soheil, Neeley, Kyle, Cong, Min, Shahbazian, Haneyeh, Dorafshani, Niki, Berrada, Achraf, MacDonagh, Alexander C., Padera, Robert F., Brugarolas, Pedro, Packard, Alan B., Rosenbaum, Matthew W., Divakaran, Sanjay, Di Carli, Marcelo F., Rashidian, Mohammad

Issue&Volume: 2025-01-22

Abstract: Imaging inflammation holds immense potential for advancing the diagnosis, treatment and prognosis of many conditions1,2,3. The lack of a specific and sensitive positron emission tomography (PET) probe to detect inflammation is a critical challenge. To bridge this gap, we present CD45-PET imaging, which detects inflammation with exceptional sensitivity and clarity in several preclinical models. Notably, the intensity of the CD45-PET signal correlates robustly with the severity of disease in models of inflammatory lung and bowel diseases, outperforming 18F-fluorodeoxyglucose PET, the most widely used imaging modality for inflammation globally. Longitudinal CD45-PET imaging further enables precise monitoring of dynamic changes in tissue-specific inflammatory profiles. Finally, we developed a human CD45-PET probe for clinical translation that effectively detects human immune cells in a humanized mouse model. CD45-PET imaging holds substantial clinical promise, offering a tool for guiding diagnostic and therapeutic decisions for inflammatory diseases through a precise, whole-body assessment of the inflammation profiles of individual patients.

DOI: 10.1038/s41586-024-08441-6

Source: https://www.nature.com/articles/s41586-024-08441-6