中国科学院分子植物科学卓越创新中心王二涛研究组发现，一对LysM受体介导地钱属中的共生与免疫区分。相关论文于2025年1月23日在线发表于国际学术期刊《细胞》。

研究人员展示了一对含有溶菌素结构域的受体样激酶（MpaLYR和MpaCERK1），在地钱Marchantia paleacea中同时介导免疫与共生。MpaLYR对长链（CO7）和短链几丁质低聚物（CO4）具有不同的亲和力。尽管CO7和CO4都可以激活与共生相关的基因，CO7在剂量依赖性上比CO4引发更强的免疫反应。

CO4能够抑制CO7引发的强免疫反应，重新呈现出与共生真菌——丛枝菌根真菌接种的早期反应。研究人员发现植物的磷饥饿会增加其产生植物激素—烟酸类物质，进而刺激丛枝菌根真菌分泌CO4/CO5，从而优先促进共生而非免疫反应。因此，一对LysM受体通过剂量依赖性地感知不同的几丁质低聚物，区分共生与致病微生物，这可能有助于植物的陆地化过程。

研究人员表示，大多数陆生植物通过与微生物的共生来获取营养，但也必须限制病原的感染。

附：英文原文

Title: A pair of LysM receptors mediates symbiosis and immunity discrimination in Marchantia

Author: Xinhang Tan, Dapeng Wang, Xiaowei Zhang, Shuang Zheng, Xiaojie Jia, Hui Liu, Zilin Liu, Hao Yang, Huiling Dai, Xi Chen, Zhixin Qian, Ran Wang, Miaolian Ma, Peng Zhang, Nan Yu, Ertao Wang

Issue&Volume: 2025-01-23

Abstract: Most land plants form symbioses with microbes to acquire nutrients but also must restrict infection by pathogens. Here, we show that a single pair of lysin-motif-containing receptor-like kinases, MpaLYR and MpaCERK1, mediates both immunity and symbiosis in the liverwort Marchantia paleacea. MpaLYR has a higher affinity for long-chain (CO7) versus short-chain chitin oligomers (CO4). Although both CO7 and CO4 can activate symbiosis-related genes, CO7 triggers stronger immune responses than CO4 in a dosage-dependent manner. CO4 can inhibit CO7-induced strong immune responses, recapitulating the early response to inoculation with the symbiont arbuscular mycorrhizal fungi. We show that phosphate starvation of plants increases their production of strigolactone, which stimulates CO4/CO5 secretion from mycorrhizal fungi, thereby prioritizing symbiosis over immunity. Thus, a single pair of LysM receptors mediates dosage-dependent perception of different chitin oligomers to discern symbiotic and pathogenic microbes in M. paleacea, which may facilitate terrestrialization.

DOI: 10.1016/j.cell.2024.12.024

Source: https://www.cell.com/cell/abstract/S0092-8674(24)01466-1