华东师范大学洪恺团队报道了基于分子间硼基转移的宝石-碘二硼化合物构建1,3-二硼基烯。相关研究成果发表在2025年1月23日出版的《中国化学》。

丙烯基硼酸酯是有价值的合成基元，引起了人们的极大兴趣。然而，它们的1,3-二酰基取代的类似物尚未被报道。

该文中，研究人员公开了一种从宝石碘二硼化合物和炔基格氏试剂制备1,3-二酰基二烯的新方法。起始材料首先转化为相应的炔丙基宝石双（硼酸酯），然后进行分子间的硼基转移，得到1,3-二酰基二烯烃，如机理研究所证实的那样。该方法具有良好的空间位阻耐受性，并与多种官能团兼容。

附：英文原文

Title: Construction of 1,3-Diboryl Allenes from gem-Iododiboron Compounds via Intermolecular Boryl Group Transfer†

Author: Ming Li, Yi Wei, Du Chen, Peng-Fei Ning, Yi-Fei Yang, Xiao-Yu Xie, Chao Liu, Kai Hong

Issue&Volume: 2025-01-23

Abstract: Allenylboronates are valuable synthetic building blocks and have garnered significant interest. However, their 1,3-diboyl substituted analogs have not been reported. Herein, we disclosed a novel method for creating 1,3-diboyl allenes from gem-iododiboron compounds and alkynyl Grignard reagents. The starting materials are initially converted into the corresponding propargylic gem-bis(boronates), which then undergo an intermolecular boryl group transfer to afford 1,3-diboyl allenes, as confirmed by mechanistic studies. This method features good tolerance to steric hindrance and is compatible with a wide variety of functional groups.

DOI: 10.1002/cjoc.202400840

Source: https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.202400840