法国国家科学研究中心Laurent Bouteiller团队报得了离子迁移率质谱法探测超分子共聚物序列。相关研究成果于2025年1月22日发表在《德国应用化学》。

超分子共聚物的微观结构因其动态特性而难以分析。

该文中，研究人员通过离子迁移质谱（IM-MS）分析苯-1,3,5-三甲酰胺（BTA）共组装体，以揭示各种序列的存在。例如，由来自第一单体的4个单元和来自第二单体的2个单元组成的六聚体的IM-MS迁移率图分布广泛，因为存在9种可能的异构体序列，可以根据计算的碰撞截面进行分类。

这种方法为超分子共聚物序列提供了前所未有的信息。

附：英文原文

Title: Ion Mobility Mass Spectrometry to Probe Sequences in Supramolecular Copolymers

Author: C, Patrick Brocorens, Laetitia-Eiko Xerri, Antoine Perennes, Geoffrey Gontard, Roberto Lazzaroni, Matthieu Raynal, Laurent Bouteiller

Issue&Volume: 2025-01-22

Abstract: The analysis of the microstructure of supramolecular copolymers is difficult because of their dynamic character. Here, benzene-1,3,5-tricarboxamide (BTA) co-assemblies are analysed by ion mobility - mass spectrometry (IM-MS) to reveal the presence of various sequences. For example, the IM-MS mobilogram for hexamers composed of 4 units from a first monomer and 2 units from a second monomer is a broad distribution due to the presence of 9 possible isomeric sequences, which can be sorted out based on calculated collision cross-sections. This approach gives unprecedented information on supramolecular copolymer sequences.

DOI: 10.1002/anie.202421328

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202421328