研究人员报告了肌肉抑制素作为一种内分泌激素的功能作用，其可直接促进小鼠垂体促卵泡激素（FSH）的合成，从而影响卵巢功能。此前，这一促进FSH合成的作用被归因于转化生长因子-β家族的其他成员——激活素。
这些研究结果不仅挑战了激活素在FSH合成中的标志性作用，还建立了一个意外的内分泌轴，连接了骨骼肌和垂体。这些数据还表明，试图拮抗肌肉抑制素以增加肌肉质量的努力，可能会对生育产生意想不到的后果。
据了解，肌肉抑制素是一种旁分泌肌肉细胞因子，调节多种物种（包括人类）的肌肉质量。
附：英文原文
Title: Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis
Author: Luisina Ongaro, Xiang Zhou, Ying Wang, Hailey Schultz, Ziyue Zhou, Evan R. S. Buddle, Emilie Brlé, Yeu-Farn Lin, Gauthier Schang, Adam Hagg, Roselyne Castonguay, Yewei Liu, Gloria H. Su, Nabil G. Seidah, Kevin C. Ray, Seth J. Karp, Ulrich Boehm, Frederique Ruf-Zamojski, Stuart C. Sealfon, Kelly L. Walton, Se-Jin Lee, Daniel J. Bernard
Issue&Volume: 2025-01-17
Abstract: Myostatin is a paracrine myokine that regulates muscle mass in a variety of species, including humans. In this work, we report a functional role for myostatin as an endocrine hormone that directly promotes pituitary follicle-stimulating hormone (FSH) synthesis and thereby ovarian function in mice. Previously, this FSH-stimulating role was attributed to other members of the transforming growth factor–β family, the activins. Our results both challenge activin’s eponymous role in FSH synthesis and establish an unexpected endocrine axis between skeletal muscle and the pituitary gland. Our data also suggest that efforts to antagonize myostatin to increase muscle mass may have unintended consequences on fertility.
DOI: adi4736
Source: https://www.science.org/doi/10.1126/science.adi4736