据介绍，负面情绪传染（目睹他人处于困境）会影响个人的情绪反应。然而，它是否会在面对未来威胁时形成应对策略仍然未知。
研究人员发现，短暂观察到同种动物受到伤害的小鼠会变得恢复力增强，在经历了不利经历后能够承受行为绝望。负面情绪感染期间的光度记录显示，外侧缰核中血清素（5-HT）的释放增加。
尽管5-羟色胺和情绪感染会减少缰核爆发，但限制5-羟色胺的合成会阻止爆发可塑性。增强中缝至缰核5-HT足以重现恢复力。相比之下，减少缰核中的5-HT释放使得目睹同种异体的痛苦无法促进逆境后的恢复力表型。
总之，这一研究表明，5-HT支持替代情绪，并通过调节缰核神经元活动的特定模式来增强恢复力。
附：英文原文
Title: Serotonin release in the habenula during emotional contagion promotes resilience
Author: Sarah Mondoloni, Patricia Molina, Salvatore Lecca, Cheng-Hsi Wu, Léo Michel, Denys Osypenko, Fanchon Cachin, Meghan Flanigan, Mauro Congiu, Arnaud L. Lalive, Thomas Kash, Fei Deng, Yulong Li, Manuel Mameli
Issue&Volume: 2024-09-06
Abstract: Negative emotional contagion—witnessing others in distress—affects an individual’s emotional responsivity. However, whether it shapes coping strategies when facing future threats remains unknown. We found that mice that briefly observe a conspecific being harmed become resilient, withstanding behavioral despair after an adverse experience. Photometric recordings during negative emotional contagion revealed increased serotonin (5-HT) release in the lateral habenula. Whereas 5-HT and emotional contagion reduced habenular burst firing, limiting 5-HT synthesis prevented burst plasticity. Enhancing raphe-to-habenula 5-HT was sufficient to recapitulate resilience. In contrast, reducing 5-HT release in the habenula made witnessing a conspecific in distress ineffective to promote the resilient phenotype after adversity. These findings reveal that 5-HT supports vicarious emotions and leads to resilience by tuning definite patterns of habenular neuronal activity.
DOI: adp3897
Source: https://www.science.org/doi/10.1126/science.adp3897