美国约翰霍普金斯大学医学院Luis A. Garza和Sam S. Lee共同合作，近期取得重要工作进展。他们研究利用团队利用异位掌侧成纤维细胞改变皮肤特性。相关研究成果2024年9月6日在线发表于
据介绍，皮肤特性受表皮和真皮的内在特征及其相互作用的控控。修改皮肤特性具有临床潜力，例如将截肢者的残肢和残端（非掌侧）皮肤转化为压力反应性掌跖（掌侧）皮肤，以提高假体使用率并最大限度地减少皮肤破裂。更大的角蛋白9（KRT9）表达、更高的表皮厚度、角质形成细胞胞浆大小、胶原蛋白长度和弹性蛋白是掌侧皮肤的标志，可能有助于掌侧皮肤弹性。
鉴于成纤维细胞具有调节角质形成细胞分化的能力，研究人员假设掌侧成纤维细胞会影响这些特征。生物打印的皮肤结构证实了掌侧成纤维细胞诱导掌侧角质形成细胞特征的能力。一项针对健康志愿者的临床试验表明，将掌侧成纤维细胞注射到非掌侧皮肤中可以增加掌侧特征，持续时间长达5个月，突显了一种潜在的细胞疗法。
附：英文原文
Title: The use of ectopic volar fibroblasts to modify skin identity
Author: Sam S. Lee, Evan Sweren, Erika Dare, Paige Derr, Kristy Derr, Chen Chia Wang, Brooke Hardesty, Aiden A. Willis, Junjie Chen, Jonathan K. Vuillier, Joseph Du, Julia Wool, Amanda Ruci, Vicky Y. Wang, Chaewon Lee, Sampada Iyengar, Soichiro Asami, Maria Daskam, Claudia Lee, Jeremy C. Lee, Darren Cho, Joshua Kim, Eddie Gibson Martinez-Pea, So Min Lee, Xu He, Michael Wakeman, Iralde Sicilia, Dalhart T. Dobbs, Amy van Ee, Ang Li, Yingchao Xue, Kaitlin L. Williams, Charles S. Kirby, Dongwon Kim, Sooah Kim, Lillian Xu, Ruizhi Wang, Marc Ferrer, Yun Chen, Jin U. Kang, Reza Kalhor, Sewon Kang, Luis A. Garza
Issue&Volume: 2024-09-06
Abstract: Skin identity is controlled by intrinsic features of the epidermis and dermis and their interactions. Modifying skin identity has clinical potential, such as the conversion of residual limb and stump (nonvolar) skin of amputees to pressure-responsive palmoplantar (volar) skin to enhance prosthesis use and minimize skin breakdown. Greater keratin 9 (KRT9) expression, higher epidermal thickness, keratinocyte cytoplasmic size, collagen length, and elastin are markers of volar skin and likely contribute to volar skin resiliency. Given fibroblasts’ capacity to modify keratinocyte differentiation, we hypothesized that volar fibroblasts influence these features. Bioprinted skin constructs confirmed the capacity of volar fibroblasts to induce volar keratinocyte features. A clinical trial of healthy volunteers demonstrated that injecting volar fibroblasts into nonvolar skin increased volar features that lasted up to 5 months, highlighting a potential cellular therapy.
DOI: adi1650
Source: https://www.science.org/doi/10.1126/science.adi1650