德国海德堡大学Julio Saez-Rodriguez团队的最新研究表明，LIANA+提供一个一体化框架用于推断细胞间通信。相关论文于2024年9月2日在线发表在《自然—细胞生物学》杂志上。

研究人员介绍了LIANA+，这是一个围绕丰富知识库构建的可扩展框架，能够从单细胞和空间解析数据中的单条件和多条件数据集中解码协调的细胞间和细胞内信号事件。

通过扩展和统一已有的方法，LIANA+提供了一套全面的协同组件，用于通过多种分子介质（包括多组学数据中测量的介质）研究细胞间通信。LIANA+可以通过https://github.com/saezlab/liana-py访问，并附有详尽的示例（https://liana-py.readthedocs.io/），为细胞间通信推断提供了一体化解决方案。

据介绍，随着单细胞和空间解析转录组学数据的日益丰富，许多方法应运而生以推断细胞间通信，但它们各自只能捕捉到细胞间信号传递复杂景观的一部分。

附：英文原文

Title: LIANA+ provides an all-in-one framework for cell–cell communication inference

Author: Dimitrov, Daniel, Schfer, Philipp Sven Lars, Farr, Elias, Rodriguez-Mier, Pablo, Lobentanzer, Sebastian, Badia-i-Mompel, Pau, Dugourd, Aurelien, Tanevski, Jovan, Ramirez Flores, Ricardo Omar, Saez-Rodriguez, Julio

Issue&Volume: 2024-09-02

Abstract: The growing availability of single-cell and spatially resolved transcriptomics has led to the development of many approaches to infer cell–cell communication, each capturing only a partial view of the complex landscape of intercellular signalling. Here we present LIANA+, a scalable framework built around a rich knowledge base to decode coordinated inter- and intracellular signalling events from single- and multi-condition datasets in both single-cell and spatially resolved data. By extending and unifying established methodologies, LIANA+ provides a comprehensive set of synergistic components to study cell–cell communication via diverse molecular mediators, including those measured in multi-omics data. LIANA+ is accessible at https://github.com/saezlab/liana-py with extensive vignettes (https://liana-py.readthedocs.io/) and provides an all-in-one solution to intercellular communication inference.

DOI: 10.1038/s41556-024-01469-w

Source: https://www.nature.com/articles/s41556-024-01469-w