中国科学院脑科学与智能技术卓越创新中心王立平等研究人员，合作实现猕猴前额叶皮层中工作记忆的空间序列的心理编程
研究人员使用高通量电生理记录研究了猕猴前额叶皮层中的心理排序。这些猕猴根据视觉线索记忆和排序空间序列，既可以向前排序，也可以向后排序。
研究人员发现，工作记忆中每个序数等级的项目被编码在不同的等级-工作记忆（WM）子空间中，然后根据线索在子空间之间保持或重新排序，并伴随着两个操作步骤中的两个额外临时子空间。
此外，线索活动作为索引信号触发排序过程。因此，研究人员提出了一个完整的概念框架，其中前额叶神经状态的神经景观转变构成了心理编程序列WM的符号系统。
据了解，大脑如何在WM中以特定顺序心理排序一系列项目仍然大量未知。
附：英文原文
Title: Mental programming of spatial sequences in working memory in the macaque frontal cortex
Author: Zhenghe Tian, Jingwen Chen, Cong Zhang, Bin Min, Bo Xu, Liping Wang
Issue&Volume: 2024-09-27
Abstract: How the brain mentally sorts a series of items in a specific order within working memory (WM) remains largely unknown. We investigated mental sorting using high-throughput electrophysiological recordings in the frontal cortex of macaque monkeys, who memorized and sorted spatial sequences in forward or backward orders according to visual cues. We discovered that items at each ordinal rank in WM were encoded in separate rank-WM subspaces and then, depending on cues, were maintained or reordered between the subspaces, accompanied by two extra temporary subspaces in two operation steps. Furthermore, the cue activity served as an indexical signal to trigger sorting processes. Thus, we propose a complete conceptual framework, where the neural landscape transitions in frontal neural states underlie the symbolic system for mental programming of sequence WM.
DOI: adp6091
Source: https://www.science.org/doi/10.1126/science.adp6091