衢州第二人民医院Cheng Yu等研究人员合作总结尿酸在中风预测和治疗中的作用。这一研究成果于2024年9月23日在线发表在国际学术期刊《神经科学通报》上。

研究人员表示，中风是一种主要的脑血管疾病，具有高发病率和死亡率。当前缺乏有效的方法来降低风险和改善预后。目前，尿酸（UA）与中风的病理机制、预后和治疗相关。UA在体内发挥促氧化/抗氧化和促炎作用。尿酸在中风中的具体作用尚不明确，可能具有神经保护和损伤效果。

血清尿酸（SUA）水平与缺血性中风（IS）之间存在U型关联。UA治疗在急性缺血性中风（AIS）的再灌注治疗中提供神经保护。降尿酸治疗（ULT）在高尿酸血症或痛风患者的IS中发挥保护作用。SUA水平与出血性中风的脑血管损伤机制、风险和结果相关。

研究人员总结了UA在中风中的作用当前研究，为其预测和治疗提供潜在靶点。

附：英文原文

Title: A New Perspective on the Prediction and Treatment of Stroke: The Role of Uric Acid

Author: Zhu, Bingrui, Huang, Xiaobin, Zhang, Jiahao, Wang, Xiaoyu, Tian, Sixuan, Zhan, Tiantong, Liu, Yibo, Zhang, Haocheng, Chen, Sheng, Yu, Cheng

Issue&Volume: 2024-09-23

Abstract: Stroke, a major cerebrovascular disease, has high morbidity and mortality. Effective methods to reduce the risk and improve the prognosis are lacking. Currently, uric acid (UA) is associated with the pathological mechanism, prognosis, and therapy of stroke. UA plays pro/anti-oxidative and pro-inflammatory roles in vivo. The specific role of UA in stroke, which may have both neuroprotective and damaging effects, remains unclear. There is a U-shaped association between serum uric acid (SUA) levels and ischemic stroke (IS). UA therapy provides neuroprotection during reperfusion therapy for acute ischemic stroke (AIS). Urate-lowering therapy (ULT) plays a protective role in IS with hyperuricemia or gout. SUA levels are associated with the cerebrovascular injury mechanism, risk, and outcomes of hemorrhagic stroke. In this review, we summarize the current research on the role of UA in stroke, providing potential targets for its prediction and treatment.

DOI: 10.1007/s12264-024-01301-3

Source: https://link.springer.com/article/10.1007/s12264-024-01301-3