上海大学陈雨团队通过理论引导的空位操纵Peierls畸变来赋予1T′-ReS₂纳米片具有声压电特性，用于肿瘤铁下垂治疗。相关研究成果于2024年9月24日发表在国际顶尖学术期刊《美国化学会杂志》。

声压电疗法利用压电材料在暴露于超声波时，有效地产生破坏性的活性氧。这种创新方法将通过无创超声控制精确靶向肿瘤部位，与通过压电效应产生高活性氧的能力相结合，为肿瘤治疗带来了希望。

该研究利用理论指导的方法，来操纵1T′-ReS₂纳米片中的原子空位缺陷并调节Peierls畸变，从而赋予它们与原始材料不同的声压电性能。此外，ReS₂纳米片丰富的不饱和位点，赋予了它们优异的过氧化氢酶和过氧化物酶模拟活性。

工程ReS₂纳米片产生的活性氧也会导致谷胱甘肽的消耗。这些能力通过涉及7成员的11-谷胱甘肽-GPX4信号轴的经典途径，用于肿瘤铁下垂治疗，同时下调二氢乳清酸脱氢酶和铁蛋白水平，上调脂肪酸辅酶A连接酶4表达。

研究成果展示了通过理论设计和材料工程，在癌症治疗中使用1T′-ReS₂纳米片的创新方法和潜在应用。

附：英文原文

Title: Endowing 1T′-ReS2 Nanosheets with Sonopiezoelectric Property by Theoretical-Guided Vacancy-Manipulated Peierls Distortion for Tumor Ferroptosis Therapy

Author: Kexing Li, Shuangshuang Wang, Chunmei Chen, Lili Xia, Hui Huang, Wei Feng, Xinyue Dai, Yu Chen

Issue&Volume: September 24, 2024

Abstract: Sonopiezoelectric therapy harnesses piezoelectric materials to efficiently generate destructive reactive oxygen species when exposed to ultrasound. This innovative approach shows promise for tumor treatment by combining precise targeting of tumor sites through noninvasive ultrasound control with high reactive oxygen species generation capabilities via the piezoelectric effect. This study utilizes a theoretical-guided method to manipulate atomic vacancy defects and regulate the Peierls distortion in 1T′-ReS2 nanosheets, thereby imparting them with sonopiezoelectric properties not inherent to the original material. Furthermore, the plentiful unsaturated sites of ReS2 nanosheets endow them with excellent catalase- and peroxidase-mimicking activities. The reactive oxygen species generation by the engineered ReS2 nanosheets also leads to the depletion of glutathione. These capabilities are leveraged for tumor ferroptosis therapy via the classical pathway involving the 7-member 11-glutathione-GPX4 signaling axis, alongside the downregulation of dihydroorotate dehydrogenase and ferritin levels and the upregulation of fatty acid CoA ligase 4 expression. This showcases the innovative approach and potential applications of employing 1T′-ReS2 nanosheets in cancer treatment through theoretical design and materials engineering.

DOI: 10.1021/jacs.4c09768

Source: https://pubs.acs.org/doi/abs/10.1021/jacs.4c09768