南方科技大学何川团队报道了不对称氢原子转移(AHAT)还原叔碳自由基。相关研究成果于2024年9月18日发表在《中国化学》。

在过去的二十年里，不对称自由基反应的发展取得了巨大的进步，已成为合成化学中合成手性分子的有力工具。在各种自由基过程中，氢原子向叔碳自由基的转移为以立体选择性方式，构建手性叔碳中心提供了潜力。

尽管存在与自由基物种的反应性和消逝性相关的挑战，但手性试剂或介质的使用，使不对称氢原子转移（AHAT）的立体控制成为可能，这为推进不对称合成领域提供了新的途径。

附：英文原文

Title: Reduction of Tertiary Carbon Radicals via Asymmetric Hydrogen Atom Transfer (AHAT)†

Author: Xue Han, Chuan He

Issue&Volume: 2024-09-18

Abstract: In the past two decades, the development of asymmetric radical reactions has achieved tremendous progress, which has emerged as a powerful tool for the synthesis of chiral molecules in synthetic chemistry. Among the diverse array of radical processes, the transfer of hydrogen atoms to tertiary carbon radicals offers the potential for constructing chiral tertiary carbon centers in a stereoselective fashion. Notwithstanding the challenges associated with the reactive and evanescent nature of radical species, the use of chiral reagents or mediators has enabled the stereocontrol of the asymmetric hydrogen atom transfer (AHAT), which provides novel avenues for advancing the field of asymmetric synthesis.

DOI: 10.1002/cjoc.202400296

Source: https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.202400296