北京大学陆林等研究人员合作总结毒品成瘾中的记忆再巩固更新：应用、机制及未来临床治疗前景。相关论文于2024年9月12日在线发表于国际学术期刊《神经科学通报》。

研究人员表示，毒品成瘾中的持续和适应不良的药物相关记忆是毒品成瘾的一个关键因素。前临床和临床研究的汇总证据表明，记忆再巩固更新程序（MRUP）具有潜在的疗效，这是一种非药理学策略，交织了两个不同的记忆过程：再巩固和消退——也称为“记忆提取-消退程序”。这一程序提供了一种有前景的方法来减轻，甚至消除，根深蒂固的药物记忆并防止复发。

研究人员回顾了MRUP在各种物质依赖背景下的应用、分子机制和操作界限。此外，研究人员还批判性地审视了MRUP的研究方法限制，并提出了优化其治疗效果的潜在改进方案。研究人员还探讨了MRUP与神经刺激治疗在物质成瘾领域潜在的结合。总体而言，现有研究强调了MRUP的重大潜力，表明基于该程序的干预可能为提升物质成瘾治疗的临床效果开辟了一条有前景的途径。

附：英文原文

Title: Memory Reconsolidation Updating in Substance Addiction: Applications, Mechanisms, and Future Prospects for Clinical Therapeutics

Author: Huang, Shihao, Liu, Xiaoxing, Li, Zhonghao, Si, Yue, Yang, Liping, Deng, Jiahui, Luo, Yixiao, Xue, Yan-Xue, Lu, Lin

Issue&Volume: 2024-09-12

Abstract: Persistent and maladaptive drug-related memories represent a key component in drug addiction. Converging evidence from both preclinical and clinical studies has demonstrated the potential efficacy of the memory reconsolidation updating procedure (MRUP), a non-pharmacological strategy intertwining two distinct memory processes: reconsolidation and extinction—alternatively termed “the memory retrieval-extinction procedure”. This procedure presents a promising approach to attenuate, if not erase, entrenched drug memories and prevent relapse. The present review delineates the applications, molecular underpinnings, and operational boundaries of MRUP in the context of various forms of substance dependence. Furthermore, we critically examine the methodological limitations of MRUP, postulating potential refinement to optimize its therapeutic efficacy. In addition, we also look at the potential integration of MRUP and neurostimulation treatments in the domain of substance addiction. Overall, existing studies underscore the significant potential of MRUP, suggesting that interventions predicated on it could herald a promising avenue to enhance clinical outcomes in substance addiction therapy.

DOI: 10.1007/s12264-024-01294-z

Source: https://link.springer.com/article/10.1007/s12264-024-01294-z