H2Se是硒化合物生物合成的前体,是一种潜在的气体传递剂。用于H2Se递送和检测的化学工具对于硒相关生物学研究非常重要。该领域的关键挑战包括开发在各种刺激下触发释放H2Se的化合物平台,以及开发能够实时跟踪H2Se递送的荧光供体。
该文中,研究人员报告了一种基于硫醇可控脱保护的触发式H2Se供体的新通用平台,该平台可以快速激活分子内芳基硒酰胺(t1/2<1分钟),有效释放H2Se。此外,研究人员利用该平台开发了荧光H2Se供体的第一个例子,可用于实时监测荧光释放的H2Se。研究认为,定义明确的供体化学物质将显著推进H2Se供体的发展,并刺激对H2Se生物医学的进一步深入研究。
附:英文原文
Title: Fast Intramolecular Thiol-Activated Arylselenoamides Provide Access to Triggered, Fluorogenic H2Se Donors
Author: Yalun Dong, Wenfang Liang, Long Yi
Issue&Volume: August 26, 2024
Abstract: H2Se is the precursor for the biosynthesis of selenocompounds and is a potential gasotransmitter. Chemical tools for H2Se delivery and detection are important for Se-related biology research. Key challenges in the field include developing compound platforms that are triggered to release H2Se under various stimuli and developing fluorogenic donors that allow for real-time tracking of H2Se delivery. Here we report a new general platform for triggered H2Se donors based on controllable deprotection of a thiol, which can quickly activate an intramolecular arylselenoamide (t1/2 < 1 min) to release H2Se efficiently. Furthermore, we leverage this platform to develop the first examples of fluorogenic H2Se donors, which can be used to monitor H2Se release by fluorescence in real time. We anticipate that the well-defined donation chemistries will significantly advance the development of H2Se donors and stimulate further in-depth studies of H2Se biomedicine.
DOI: 10.1021/jacs.4c09215
Source: https://pubs.acs.org/doi/abs/10.1021/jacs.4c09215
JACS:《美国化学会志》,创刊于1879年。隶属于美国化学会,最新IF:16.383
官方网址:https://pubs.acs.org/journal/jacsat
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