华东理工大学刘润辉团队报道了N -羧酸氢化物(NCA)开环聚合法制备多肽的研究进展与展望。相关研究成果发表在2024年8月22日出版的《美国化学会杂志》。

多肽与蛋白质和肽具有相同或相似的骨架结构，使其成为合适和重要的生物材料。随着引发剂、催化剂和反应条件的不断改进，氨基酸N-羧酸酐（NCA）开环聚合已成为制备多肽的最有效策略。

该文首先总结了NCA合成和纯化的最新进展。随后，研究人员重点介绍了NCA聚合的各种引发剂、加速聚合或增强聚合可控性的催化剂，以及NCA聚合反应方法的最新进展。最后，讨论了未来的研究方向和面临的挑战。

附：英文原文

Title: Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization

Author: Yueming Wu, Kang Chen, Jiangzhou Wang, Minzhang Chen, Wenhui Dai, Runhui Liu

Issue&Volume: August 22, 2024

Abstract: Polypeptides have the same or similar backbone structures as proteins and peptides, rendering them as suitable and important biomaterials. Amino acid N-carboxyanhydrides (NCA) ring-opening polymerization has been the most efficient strategy for polypeptide preparation, with continuous advance in the design of initiators, catalysts and reaction conditions. This Perspective first summarizes the recent progress of NCA synthesis and purification. Subsequently, we focus on various initiators for NCA polymerization, catalysts for accelerating polymerization or enhancing the controllability of polymerization, and recent advances in the reaction approach of NCA polymerization. Finally, we discuss  future research directions and open challenges.

DOI: 10.1021/jacs.4c05382

Source: https://pubs.acs.org/doi/abs/10.1021/jacs.4c05382