复旦大学王英伟等研究人员合作总结全身麻醉的神经网络机制——皮层与皮层下核团的作用。该研究于2024年8月21日在线发表于国际一流学术期刊《神经科学通报》。

研究人员总结了当前关于皮层和皮层下核团在调节全身麻醉中的作用的理解，提供与麻醉和意识相关的皮层-皮层和丘脑-皮层网络的新证据。这些见解有助于全面理解全身麻醉背后的神经网络机制。

据悉，全身麻醉在现代医学中具有重要作用，但其精确的机制仍然不清楚，构成了麻醉学中的一个关键科学挑战。神经科学技术的进步使得对特定神经回路的靶向操作和捕捉全脑神经活动的高分辨率成为可能，这为阐明全身麻醉药物的复杂作用机制带来了希望。

附：英文原文

Title: Neural Network Mechanisms Underlying General Anesthesia: Cortical and Subcortical Nuclei

Author: Hu, Yue, Wang, Yun, Zhang, Lingjing, Luo, Mengqiang, Wang, Yingwei

Issue&Volume: 2024-08-21

Abstract: General anesthesia plays a significant role in modern medicine. However, the precise mechanism of general anesthesia remains unclear, posing a key scientific challenge in anesthesiology. Advances in neuroscience techniques have enabled targeted manipulation of specific neural circuits and the capture of brain-wide neural activity at high resolution. These advances hold promise for elucidating the intricate mechanisms of action of general anesthetics. This review aims to summarize our current understanding of the role of cortical and subcortical nuclei in modulating general anesthesia, providing new evidence of cortico-cortical and thalamocortical networks in relation to anesthesia and consciousness. These insights contribute to a comprehensive understanding of the neural network mechanisms underlying general anesthesia.

DOI: 10.1007/s12264-024-01286-z

Source: https://link.springer.com/article/10.1007/s12264-024-01286-z