吉林大学杨英威团队报道了主客体相互作用和金属配位驱动的自组装纳米螺旋。相关研究成果于2024年8月20日发表于国际一流学术期刊《德国应用化学》。

通过人工基序的自组装制备的螺旋纳米结构，因其结构美学和多种功能而成为一个引人入演讲热点。

该文中，研究人员报告了通过利用非手性聚集诱导发射（AIE）发光体（G）和柱状[5]芳烃（H），在主客体相互作用和金属配位的驱动下，轻松构建自组装纳米螺旋（NH）。

受“手性非线性放大”效应和“多数决定规则”原理的启发，G和H之间的主客体络合被用来固定G的扭曲构象，以产生“扭曲位点”，这进一步诱导了螺旋性的出现，因为1D组件是通过Ag（I）配位形成的，并被六边形包装成纳米级纤维。

该策略已被证明在均相和非均相合成中都是可行的。随着NH的形成，由于对G的有效限制，活性氧（ROS）的发光增强和生产率提高，表明NH的形态和光物理性质同时受到超分子组装的调节。

此外，NH还表现出对金黄色葡萄球菌(S. aurethem)和大肠杆菌(E. coli)的细菌成像和光动力抗菌活性。

附：英文原文

Title: Self-Assembled Nanohelixes Driven by Host-Guest Interactions and Metal Coordination

Author: Xin-Yue Lou, Kun Zhang, Yujie Bai, Siyuan Zhang, Yuanyuan Li, Ying-Wei Yang

Issue&Volume: 2024-08-20

Abstract: Helical nanostructures fabricated via the self-assembly of artificial motifs have been a captivating subject because of their structural aesthetics and multiple functionalities. Herein, we report the facile construction of a self-assembled nanohelix (NH) by leveraging an achiral aggregation-induced emission (AIE) luminogen (G) and pillar[5]arene (H), driven by host-guest interactions and metal coordination. Inspired by the “sergeants and soldiers” effect and “majority rule” principle, the host-guest complexation between G and H is employed to fixate the twisted conformation of G for the generation of “contortion sites”, which further induced the emergence of helicity as the 1D assemblies are formed via Ag(I) coordination and hexagonally packed into nano-sized fibers. The strategy has proved feasible in both homogeneous and heterogeneous syntheses. Along with the formation of NH, boosted luminescence and enhanced productivity of reactive oxygen species (ROS) are afforded because of the efficient restriction on G, indicating the concurrent regulation of NH's morphology and photophysical properties by supramolecular assembly. In addition, NH also exhibits the capacity for bacteria imaging and photodynamic antibacterial activities against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli).

DOI: 10.1002/anie.202414611

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202414611