近日，海军医科大学苏志达等研究人员合作总结星形胶质细胞的生理学和病理学。2024年7月30日，《神经科学通报》杂志在线发表了这篇论文。

研究人员表示，在哺乳动物中枢神经系统（CNS）中，星形胶质细胞是广泛存在的胶质细胞，具有复杂的形态学和分子特征。这些迷人的细胞在健康的CNS中发挥着至关重要的神经支持和稳态作用，并在响应CNS损伤或疾病时经历形态学、分子和功能上的变化，进入所谓的“反应性”状态。

近年来，由于技术的进步，对星形胶质细胞的研究兴趣显著增加，发现了这些细胞在生理和病理条件下的新生物特征和作用。

研究人员回顾和讨论了已建立和新兴的星形胶质细胞生物学及其功能，重点讨论其作为CNS损伤（包括创伤性和缺血性损伤）治疗靶点的潜力。研究人员强调了星形胶质细胞在CNS损伤的神经病理过程和修复中的重要性。

附：英文原文

Title: From Physiology to Pathology of Astrocytes: Highlighting Their Potential as Therapeutic Targets for CNS Injury

Author: Yuan, Yimin, Liu, Hong, Dai, Ziwei, He, Cheng, Qin, Shangyao, Su, Zhida

Issue&Volume: 2024-07-30

Abstract: In the mammalian central nervous system (CNS), astrocytes are the ubiquitous glial cells that have complex morphological and molecular characteristics. These fascinating cells play essential neurosupportive and homeostatic roles in the healthy CNS and undergo morphological, molecular, and functional changes to adopt so-called ‘reactive’ states in response to CNS injury or disease. In recent years, interest in astrocyte research has increased dramatically and some new biological features and roles of astrocytes in physiological and pathological conditions have been discovered thanks to technological advances. Here, we will review and discuss the well-established and emerging astroglial biology and functions, with emphasis on their potential as therapeutic targets for CNS injury, including traumatic and ischemic injury. This review article will highlight the importance of astrocytes in the neuropathological process and repair of CNS injury.

DOI: 10.1007/s12264-024-01258-3

Source: https://link.springer.com/article/10.1007/s12264-024-01258-3