美国加州大学伯克利分校Andrew Dillin小组发现，生殖系协调线粒体细胞因子信号转导。2024年7月2日，国际知名学术期刊《细胞》在线发表了这一成果。
研究人员发现生殖系线粒体在神经元到外周的线粒体未折叠蛋白反应（UPRMT）信号传导中发挥着令人惊讶的作用。具体来说，研究人员发现生殖系线粒体在神经元线粒体细胞因子、Wnt和血清素的下游以及外周脂质代谢途径的上游发出信号，以调节UPRMT的激活。
研究人员还发现，生殖系组织本身对UPRMT信号传导至关重要。研究人员提出，生殖系在协调各组织间线粒体应激反应方面发挥着核心信号作用，而生殖系线粒体由于其在生殖系完整性和组织间信号传递方面的固有作用，在这种协调中发挥着决定性作用。
据悉，线粒体协调跨组织应激反应的能力对健康至关重要。在秀丽隐杆线虫中，经历线粒体应激的神经元通过释放线粒体细胞因子信号（如血清素或Wnt配体EGL-20）引发组织间信号通路，从而激活外周的UPRMT，促进生物体的健康和寿命。
附：英文原文
Title: The germline coordinates mitokine signaling
Author: Koning Shen, Jenni Durieux, Cesar G. Mena, Brant M. Webster, C. Kimberly Tsui, Hanlin Zhang, Larry Joe, Kristen M. Berendzen, Andrew Dillin
Issue&Volume: 2024-07-02
Abstract: The ability of mitochondria to coordinate stress responses across tissues is criticalfor health. In C. elegans, neurons experiencing mitochondrial stress elicit an inter-tissue signaling pathwaythrough the release of mitokine signals, such as serotonin or the Wnt ligand EGL-20,which activate the mitochondrial unfolded protein response (UPRMT) in the periphery to promote organismal health and lifespan. We find that germlinemitochondria play a surprising role in neuron-to-periphery UPRMT signaling. Specifically, we find that germline mitochondria signal downstream ofneuronal mitokines, Wnt and serotonin, and upstream of lipid metabolic pathways inthe periphery to regulate UPRMT activation. We also find that the germline tissue itself is essential for UPRMT signaling. We propose that the germline has a central signaling role in coordinatingmitochondrial stress responses across tissues, and germline mitochondria play a definingrole in this coordination because of their inherent roles in germline integrity andinter-tissue signaling.
DOI: 10.1016/j.cell.2024.06.010
Source: https://www.cell.com/cell/abstract/S0092-8674(24)00650-0