清华大学俞立团队发现。中性粒细胞衍生的迁移体是凝血系统的重要组成部分。相关论文于2024年7月12日在线发表于国际学术期刊《自然—细胞生物》。

研究人员报告了中性粒细胞来源的迁移体在止血中的关键作用。研究发现，在小鼠和人类的血液中存在大量的中性粒细胞来源的迁移体。与中性粒细胞体和血小板相比，这些迁移体在其表面吸附和富集了凝血因子。此外，它们高度富集了粘附分子，使其优先积聚在受伤部位，从而触发血小板激活和凝血。中性粒细胞的耗竭或这些迁移体数量的基因减少显著降低了血小板栓塞形成并损害了凝血。

这些缺陷可以通过静脉注射纯化的中性粒细胞来源的迁移体来补救。该研究揭示了中性粒细胞来源的迁移体是止血系统中一个此前未被认识的关键组成部分，这可能为各种凝血障碍的原因提供线索并开辟治疗可能性。

据了解，迁移体是由迁移细胞生成的细胞器。

附：英文原文

Title: Neutrophil-derived migrasomes are an essential part of the coagulation system

Author: Jiang, Dong, Jiao, Lin, Li, Qing, Xie, Renxiang, Jia, Haohao, Wang, ShiHui, Chen, Yining, Liu, Siyuan, Huang, Dandan, Zheng, Jiajia, Song, Wenhao, Li, Ying, Chen, JianFeng, Li, Jinsong, Ying, Binwu, Yu, Li

Issue&Volume: 2024-07-12

Abstract: Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found that a large number of neutrophil-derived migrasomes exist in the blood of mice and humans. Compared with neutrophil cell bodies and platelets, these migrasomes adsorb and enrich coagulation factors on the surface. Moreover, they are highly enriched with adhesion molecules, which enable them to preferentially accumulate at sites of injury, where they trigger platelet activation and clot formation. Depletion of neutrophils, or genetic reduction of the number of these migrasomes, significantly decreases platelet plug formation and impairs coagulation. These defects can be rescued by intravenous injection of purified neutrophil-derived migrasomes. Our study reveals neutrophil-derived migrasomes as a previously unrecognized essential component of the haemostasis system, which may shed light on the cause of various coagulation disorders and open therapeutic possibilities.

DOI: 10.1038/s41556-024-01440-9

Source: https://www.nature.com/articles/s41556-024-01440-9