复旦大学Yu Gu团队近期取得重要工作进展，他们研究提出，高镁通过TRPM7促进弱视患者双眼视力的恢复。相关研究成果2024年6月4日在线发表于《神经科学通报》杂志上。

据介绍，关键时期的异常视觉体验会导致视觉功能缺陷，如弱视。补充高镁（Mg²⁺）可以恢复眼优势（OD）的可塑性，促进成人弱视视力的恢复。然而，Mg²⁺是否能恢复成人弱视患者的双眼视觉，以及其恢复的分子机制是什么，目前尚不清楚。

研究人员发现，在高Mg²⁺治疗的弱视小鼠中，除了OD可塑性的恢复外，双眼整合也可以恢复。在行为上，Mg²⁺处理的弱视小鼠表现出更好的深度感知。

此外，高Mg²⁺的作用可以通过瞬时受体电位的TRPM7敲低来抑制。

总之，这一研究表明，高Mg²⁺可以恢复弱视患者的双眼视觉功能。TRPM7是高Mg²⁺治疗后视觉皮层可塑性恢复所必需的，它可以为未来弱视的研究和治疗提供可能的临床应用。

附：英文原文

Title: High Magnesium Promotes the Recovery of Binocular Vision from Amblyopia via TRPM7

Author: Dai, Menghan, Li, Jie, Hao, Xiangwen, Li, Na, Zheng, Mingfang, He, Miao, Gu, Yu

Issue&Volume: 2024-06-04

Abstract: Abnormal visual experience during the critical period can cause deficits in visual function, such as amblyopia. High magnesium (Mg2+) supplementary can restore ocular dominance (OD) plasticity, which promotes the recovery of amblyopic eye acuity in adults. However, it remains unsolved whether Mg2+ could recover binocular vision in amblyopic adults and what the molecular mechanism is for the recovery. We found that in addition to the recovery of OD plasticity, binocular integration can be restored under the treatment of high Mg2+ in amblyopic mice. Behaviorally, Mg2+-treated amblyopic mice showed better depth perception. Moreover, the effect of high Mg2+ can be suppressed with transient receptor potential melastatin-like 7 (TRPM7) knockdown. Collectively, our results demonstrate that high Mg2+ could restore binocular visual functions from amblyopia. TRPM7 is required for the restoration of plasticity in the visual cortex after high Mg2+ treatment, which can provide possible clinical applications for future research and treatment of amblyopia.

DOI: 10.1007/s12264-024-01242-x

Source: https://link.springer.com/article/10.1007/s12264-024-01242-x