中国科学院大学Yong Liu等研究人员合作揭示轻度认知障碍和阿尔茨海默病的神经影像学和分子特征。相关论文于2024年6月1日在线发表在《神经科学通报》杂志上。

研究人员旨在评估阿尔茨海默病（AD）区域性脑萎缩的易感性及其生物学机制。研究人员进行了数据驱动的荟萃分析，将来自三个数据集的3118张结构性磁共振图像结合起来，获得了稳健的萎缩模式。然后，研究人员引入了一组放射基因组学分析，以研究AD萎缩模式的生物学基础。结果显示，在轻度认知障碍（MCI）和AD中，海马和杏仁核的萎缩最为严重，其次是颞叶、额叶和枕叶。MCI的脑萎缩程度不如AD严重。

通过基因组富集分析，研究人员揭示了与谷氨酸信号通路、细胞应激反应以及突触结构和功能相关的一系列生物学过程。该研究有助于了解萎缩的表现形式，加深对导致萎缩的病理生理过程的认识，为进一步开展AD临床研究提供新的见解。

附：英文原文

Title: Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer’s Disease: A Data-Driven Meta-Analysis with N = 3,118

Author: Kang, Xiaopeng, Wang, Dawei, Lin, Jiaji, Yao, Hongxiang, Zhao, Kun, Song, Chengyuan, Chen, Pindong, Qu, Yida, Yang, Hongwei, Zhang, Zengqiang, Zhou, Bo, Han, Tong, Liao, Zhengluan, Chen, Yan, Lu, Jie, Yu, Chunshui, Wang, Pan, Zhang, Xinqing, Li, Ming, Zhang, Xi, Jiang, Tianzi, Zhou, Yuying, Liu, Bing, Han, Ying, Liu, Yong

Issue&Volume: 2024-06-01

Abstract: The current study aimed to evaluate the susceptibility to regional brain atrophy and its biological mechanism in Alzheimer’s disease (AD). We conducted data-driven meta-analyses to combine 3,118 structural magnetic resonance images from three datasets to obtain robust atrophy patterns. Then we introduced a set of radiogenomic analyses to investigate the biological basis of the atrophy patterns in AD. Our results showed that the hippocampus and amygdala exhibit the most severe atrophy, followed by the temporal, frontal, and occipital lobes in mild cognitive impairment (MCI) and AD. The extent of atrophy in MCI was less severe than that in AD. A series of biological processes related to the glutamate signaling pathway, cellular stress response, and synapse structure and function were investigated through gene set enrichment analysis. Our study contributes to understanding the manifestations of atrophy and a deeper understanding of the pathophysiological processes that contribute to atrophy, providing new insight for further clinical research on AD.

DOI: 10.1007/s12264-024-01218-x

Source: https://link.springer.com/article/10.1007/s12264-024-01218-x