清华大学俞立等研究人员合作揭示迁移体介导的局部高效分泌信号蛋白。该研究于2024年6月25日在线发表于国际一流学术期刊《细胞研究》。

据了解，迁移体富含趋化因子、细胞因子和血管生成因子等信号分子，在这些分子的空间传递中发挥着关键作用，影响着器官形态发生和血管生成等关键生理过程。信号分子在迁移体中的积累机制一直难以捉摸。

附：英文原文

Title: Localized, highly efficient secretion of signaling proteins by migrasomes

Author: Jiao, Haifeng, Li, Xiaopeng, Li, Ying, Guo, Yuting, Hu, Xiaoyu, Sho, Takami, Luo, Yiqun, Wang, Jinyu, Cao, Huizhen, Du, Wanqing, Li, Dong, Yu, Li

Issue&Volume: 2024-06-25

Abstract: Migrasomes, enriched with signaling molecules such as chemokines, cytokines and angiogenic factors, play a pivotal role in the spatially defined delivery of these molecules, influencing critical physiological processes including organ morphogenesis and angiogenesis. The mechanism governing the accumulation of signaling molecules in migrasomes has been elusive. In this study, we show that secretory proteins, including signaling proteins, are transported into migrasomes by secretory carriers via both the constitutive and regulated secretion pathways. During cell migration, a substantial portion of these carriers is redirected to the rear of the cell and actively transported into migrasomes, driven by the actin-dependent motor protein Myosin-5a. Once at the migrasomes, these carriers fuse with the migrasome membrane through SNARE-mediated mechanisms. Inhibiting migrasome formation significantly reduces secretion, suggesting migrasomes as a principal secretion route in migrating cells. Our findings reveal a specialized, highly localized secretion paradigm in migrating cells, conceptually paralleling the targeted neurotransmitter release observed in neuronal systems.

DOI: 10.1038/s41422-024-00992-7

Source: https://www.nature.com/articles/s41422-024-00992-7