杭州师范大学方显杰团队综述了镍对映选择性催化构建无环季碳立体中心。相关研究成果于2024年6月21日发表于国际一流学术期刊《中国化学》。

在许多生物活性化合物、药物和天然产物中普遍存在的无环季碳立体中心的构建，是合成有机化学中的一项长期任务。在众多方法中，对映选择性镍催化近年来越来越受到关注。

该文综述了近年来通过对映选择性镍催化生成无环季碳立体中心的不对称策略、研究进展和机理研究的最新进展。

附：英文原文

Title: Construction of Acyclic Quaternary Carbon Stereocenters via Enantioselective Nickel Catalysis†

Author: Jian Song, Xuening Li, Jinguo Long, Hua Yang, Xianjie Fang

Issue&Volume: 2024-06-21

Abstract: The construction of acyclic quaternary carbon stereocenters, which are ubiquitous in many bioactive compounds, pharmaceuticals and natural products, has been a long persuit in synthetic organic chemistry. Among numerous methods, enantioselective nickel-catalysis has attracted incremental attention in recent years. This review summarizes the recent development in the asymmetric strategies, research progress, mechanistic investigations for the generation of acyclic quaternary carbon stereocenters via enantioselective nickel catalysis.

DOI: 10.1002/cjoc.202400260

Source: https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.202400260